The Brain-Gut Axis in Health and Disease

  • Yasser Al Omran
  • Qasim Aziz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 817)


The interaction between the brain and the gut has been recognized for many centuries. This bidirectional interaction occurs via neural, immunological and hormonal routes, and is important not only in normal gastrointestinal function but also plays a significant role in shaping higher cognitive function such as our feelings and our subconscious decision-making. Therefore, it remains unsurprising that perturbations in normal signalling have been associated with a multitude of disorders, including inflammatory and functional gastrointestinal disorders, and eating disorders.


Inflammatory Bowel Disease Irritable Bowel Syndrome Anorexia Nervosa Anterior Cingulate Cortex Eating Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.





Anterior cingulate cortex




Autonomic nervous system


Cholecystokinin 1 receptor


Central nervous system


Corticotropin-releasing factor


Dorsal motor nucleus of the vagus


Emotional motor system


Fibroblast growth factor 19


Functional magnetic resonance imaging


Gut-associated lymphoid tissue




Glucagon-like peptide-1


G-protein coupled receptor




Inflammatory bowel disease


Irritable bowel syndrome


Klotho beta

NF- κB

Nuclear factor κB


Neuropeptide Y


Orbitofrontal cortex


Periaqueductal grey


Prefrontal cortex


Tumor necrosis factor-α


α7 nicotinic acetylcholine receptor


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Copyright information

© Springer New York 2014

Authors and Affiliations

  1. 1.Centre for Digestive Diseases, Wingate Institute of Neurogastroenterology, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen MaryUniversity of LondonLondonUK
  2. 2.Bart’s and The London NHS Trust, Centre for GastroenterologyThe Wingate Institute of NeurogastroenterologyLondonUK

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