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Nutritional and Endocrinologic Complications

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Part of the book series: Respiratory Medicine ((RM))

Abstract

Nutrition support plays an important role in the management of critical illness. Our understanding of the difference between the impact of catabolism and that of nourishment in critical illness continues to evolve. In this chapter we will discuss the new diagnostic criteria for malnutrition in the setting of uncontrolled catabolism of critical illness.

Numerous recent studies have investigated the role that adjunctive nutritional therapies may play in ameliorating the metabolic response to stress as seen in critical illness. We will discuss the role of micronutrient deficiencies and attempts at supplementation, and critically analyze their effectiveness.

Both parenteral and enteral nutrition have important roles to play in the ICU. The route, timing and potential risks of each strategy will be discussed in depth. Particular attention will be made to refeeding syndrome, a potentially life-threatening condition when not recognized or anticipated.

Lastly, we will address aspects of the management of endocrine-related issues in the critically ill patient. Management of blood glucose, thyroid disease and adrenal insufficiency will be discussed at length.

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References

  1. Norman K, Pichard C, Lochs H, Pirlich M. Prognostic impact of disease-related malnutrition. Clin Nutr. 2008;27:5.

    Article  PubMed  Google Scholar 

  2. Manzanares W, Dhaliwal R, Jiang X, Murch L, Heyland DK. Antioxidant micronutrients in the critically ill: a systematic review and meta-analysis. Crit Care. 2012;16(2):R66.

    Article  PubMed Central  PubMed  Google Scholar 

  3. Singer P, Berger MM, Van den Berghe G, Biolo G, Calder P, Forbes A, et al. ESPEN guidelines on parenteral nutrition: intensive care. Clin Nutr. 2009;28(4):387–400.

    Article  PubMed  Google Scholar 

  4. Manzanares W, Hardy G. Thiamine supplementation in the critically ill. Curr Opin Clin Nutr Metab Care. 2011;14(6):610–7.

    Article  CAS  PubMed  Google Scholar 

  5. NCGCACC 2010 National Clinical Guideline Centre for Acute and Chronic Conditions. Clinical guideline 100. London: Royal College of Physicians; 2010.

    Google Scholar 

  6. Ambrose ML, Bowden SC, Whelan G. Thiamin treatment and working memory function of alcohol-dependent people: preliminary findings. Alcohol Clin Exp Res. 2001;25(1):112–6.

    Article  CAS  PubMed  Google Scholar 

  7. Agay D, Sandre C, Ducros V, et al. Optimization of selenium status by a single intra-peritoneal injection of Se in Se deficient rat: possible application to burned patient treatment. Free Radic Biol Med. 2005;39:762–8.

    Article  CAS  PubMed  Google Scholar 

  8. Angstwurm MW, Schottdorf J, Schopohl J, Gaertner R. Selenium replacement in patients with severe systemic inflammatory response syndrome improves clinical outcome. Crit Care Med. 1999;27(9):1807–13.

    Article  CAS  PubMed  Google Scholar 

  9. Angstwurm MW, Engelmann L, Zimmermann T, Lehmann C, Spes CH, Abel P, et al. Selenium in intensive care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock. Crit Care Med. 2007;35(1):118–26.

    Article  CAS  PubMed  Google Scholar 

  10. Manzanares W, Biestro A, Torre MH, Galusso F, Facchin G, Hardy G. High-dose selenium reduces ventilator-associated pneumonia and illness severity in critically ill patients with systemic inflammation. Intensive Care Med. 2011;37(7):1120–7.

    Article  CAS  PubMed  Google Scholar 

  11. Forceville X, Laviolle B, Annane D, Vitoux D, Bleichner G, Korach JM, et al. Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study. Crit Care. 2007;11(4):R73.

    Article  PubMed Central  PubMed  Google Scholar 

  12. Andrews PJ, Avenell A, Noble DW, Campbell MK, Croal BL, Simpson WG, et al. Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients. BMJ. 2011;342:d1542.

    Article  PubMed  Google Scholar 

  13. Heyland D, Muscedere J, Wischmeyer PE, Cook D, Jones G, Albert M, et al. A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med. 2013;368(16): 1489–97.

    Article  CAS  PubMed  Google Scholar 

  14. Hardy G, Hardy I, Manzanares W. Selenium supplementation in the critically ill. Nutr Clin Pract. 2012;27(1):21–33.

    Article  PubMed  Google Scholar 

  15. Rayman MP. Selenium and human health. Lancet. 2012;379(9822):1256–68.

    Article  CAS  PubMed  Google Scholar 

  16. Jackson NC, Carroll PV, Russell-Jones DL, Sönksen PH, Treacher DF, Umpleby AM. The metabolic consequences of critical illness: acute effects on glutamine and protein metabolism. Am J Physiol. 1999;276(1 Pt 1):E163–70.

    CAS  PubMed  Google Scholar 

  17. Bongers T, Griffiths RD, McArdle A. Exogenous glutamine: the clinical evidence. Crit Care Med. 2007;35(9 Suppl):S545–52.

    Article  CAS  PubMed  Google Scholar 

  18. Novak F, Heyland DK, Avenell A, Drover JW, Su X. Glutamine supplementation in serious illness: a systematic review of the evidence. Crit Care Med. 2002;30(9):2022–9.

    Article  CAS  PubMed  Google Scholar 

  19. Lee P, Eisman JA, Center JR. Vitamin D deficiency in critically ill patients. N Engl J Med. 2009;360(18):1912–4.

    Article  CAS  PubMed  Google Scholar 

  20. Nathens AB, Neff MJ, Jurkovich GJ, Klotz P, Farver K, Ruzinski JT, et al. Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients. Ann Surg. 2002;236(6):814–22.

    Article  PubMed Central  PubMed  Google Scholar 

  21. McClave SA, Martindale RG, Vanek VW, McCarthy M, Roberts P, Taylor B, et al. Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). JPEN J Parenter Enteral Nutr. 2009;33(3):277–316.

    Article  PubMed  Google Scholar 

  22. Seres DS, Valcarcel M, Guillaume A. Advantages of enteral nutrition over parenteral nutrition. Therap Adv Gastroenterol. 2013;6(2):157–67.

    Article  PubMed Central  PubMed  Google Scholar 

  23. Harper CG, Giles M, Finlay-Jones R. Clinical signs in the Wernicke–Korsakoff complex: a retrospective analysis of131 cases diagnosed at necropsy. J Neurol Neurosurg Psychiatry. 1986;49:341–5.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  24. Sorokin R, Gottlieb JE. Enhancing patient safety during feeding-tube insertion: a review of more than 2,000 insertions. JPEN J Parenter Enteral Nutr. 2006;30(5):440–5.

    Article  PubMed  Google Scholar 

  25. Amorosa JK, Bramwit MP, Mohammed TL, Reddy GP, Brown K, Dyer DS, et al. ACR appropriateness criteria routine chest radiographs in intensive care unit patients. J Am Coll Radiol. 2013;10(3):170–4.

    Article  PubMed  Google Scholar 

  26. Seguin P, Le Bouquin V, Aguillon D, Maurice A, Laviolle B, Mallédant Y. Testing nasogastric tube placement: evaluation of three different methods in intensive care unit. Ann Fr Anesth Reanim. 2005;24(6):594–9.

    Article  CAS  PubMed  Google Scholar 

  27. Hensel M, Marnitz R. Pneumothorax following nasogastric feeding tube insertion: case report and review of the literature. Anaesthesist. 2010;59(3):229–32. 234.

    Article  CAS  PubMed  Google Scholar 

  28. Genú PR, de Oliveira DM, Vasconcellos RJ, Nogueira RV, Vasconcelos BC. Inadvertent intracranial placement of a nasogastric tube in a patient with severe craniofacial trauma: a case report. J Oral Maxillofac Surg. 2004;62(11):1435–8.

    Article  PubMed  Google Scholar 

  29. Safdar N, Dezfulian C, Collard H, et al. Clinical and economic consequences of ventilator-associated pneumonia: a systematic review. Crit Care Med. 2005;33:2184–93.

    Article  PubMed  Google Scholar 

  30. Bonten MJ, Gaillard CA, de Leeuw PW, Stobberingh EE. Role of colonization of the upper intestinal tract in the pathogenesis of ventilator associated pneumonia. Clin Infect Dis. 1997;24:309–19.

    Article  CAS  PubMed  Google Scholar 

  31. Torres A, Serra-Batlles J, Ros E, Piera C, Puig de la Bellacasa J, Cobos A, et al. Pulmonary aspiration of gastric contents in patients receiving mechanical ventilation: the effect of body position. Ann Intern Med. 1992;116:540–3.

    Article  CAS  PubMed  Google Scholar 

  32. Carrilho CM, Grion CM, Bonametti AM, Medeiros EA, Matsuo T. Multivariate analysis of the factors associated with the risk of pneumonia in intensive care units. Braz J Infect Dis. 2007;11(3):339–44.

    Article  PubMed  Google Scholar 

  33. Tejada Artigas A, Bello Dronda S, Chacón Vallés E, Muñoz Marco J, Villuendas Usón MC, Figueras P, et al. Risk factors for nosocomial pneumonia in critically ill trauma patients. Crit Care Med. 2001;29(2):304–9.

    Article  CAS  PubMed  Google Scholar 

  34. Wolkewitz M, Vonberg RP, Grundmann H, Beyersmann J, Gastmeier P, Bärwolff S, et al. Risk factors for the development of nosocomial pneumonia and mortality on intensive care units: application of competing risks models. Crit Care. 2008;12(2):R44.

    Article  PubMed Central  PubMed  Google Scholar 

  35. Reignier J, Mercier E, Le Gouge A, Boulain T, Desachy A, Bellec F, et al. Effect of not monitoring residual gastric volume on risk of ventilator-associated pneumonia in adults receiving mechanical ventilation and early enteral feeding: a randomized controlled trial. JAMA. 2013;309(3):249–56.

    Article  CAS  PubMed  Google Scholar 

  36. Muscedere J, Rewa O, McKechnie K, Jiang X, Laporta D, Heyland DK. Subglottic secretion drainage for the prevention of ventilator associated pneumonia: a systematic review and meta-analysis. Crit Care Med. 2011;39:1985–91.

    Article  PubMed  Google Scholar 

  37. Chan EY, Ruest A, Meade MO, Cook DJ. Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis. BMJ. 2007;334(7599):889.

    Article  PubMed Central  PubMed  Google Scholar 

  38. Alhazzani W, Smith O, Muscedere J, Medd J, Cook D. Toothbrushing for critically ill mechanically ventilated patients: a systematic review and meta-analysis of randomized trials evaluating ventilator-associated pneumonia. Crit Care Med. 2013;41(2):646–55.

    Article  PubMed  Google Scholar 

  39. Hsu CW, Sun SF, Lin SL, Kang SP, Chu KA, Lin CH, et al. Duodenal versus gastric feeding in medical intensive care unit patients: a prospective, randomized, clinical study. Crit Care Med. 2009;37(6):1866–72.

    Article  PubMed  Google Scholar 

  40. Heyland DK, Drover JW, MacDonald S, Novak F, Lam M. Effect of postpyloric feeding on gastroesophageal regurgitation and pulmonary microaspiration: results of a randomized controlled trial. Crit Care Med. 2001;29:1495–501.

    Article  CAS  PubMed  Google Scholar 

  41. Ho KM, Dobb GJ, Webb SA. A comparison of early gastric and post-pyloric feeding in critically ill patients: a meta-analysis. Intensive Care Med. 2006;32:639–49.

    Article  PubMed  Google Scholar 

  42. Marik PE, Zaloga GP. Gastric versus post-pyloric feeding: a systematic review. Crit Care. 2003;7:R46–51.

    Article  PubMed Central  PubMed  Google Scholar 

  43. Rhoney DH, Parker Jr D, Formea CM, Yap C, Coplin WM. Tolerability of bolus versus continuous gastric feeding in brain-injured patients. Neurol Res. 2002;24(6):613–20.

    Article  PubMed  Google Scholar 

  44. Bowling TE, Cliff B, Wright JW, Blackshaw PE, Perkins AC, Lobo DN. The effects of bolus and continuous nasogastric feeding on gastro-oesophageal reflux and gastric emptying in healthy volunteers: a randomised three-way crossover pilot study. Clin Nutr. 2008;27(4):608–13.

    Article  PubMed  Google Scholar 

  45. Serpa LF, Kimura M, Faintuch J, Ceconello I. Effects of continuous versus bolus infusion of enteral nutrition in critical patients. Rev Hosp Clin Fac Med Sao Paulo. 2003;58(1):9–14.

    Article  PubMed  Google Scholar 

  46. Booth CM, Heyland DK, Paterson WG. Gastrointestinal promotility drugs in the critical care setting: a systematic review of the evidence. Crit Care Med. 2002;30:1429–35.

    Article  CAS  PubMed  Google Scholar 

  47. Deehan S, Dobb GJ. Metoclopramide-induced raised intracranial pressure after head injury. J Neurosurg Anesthesiol. 2002;14(2):157–60.

    Article  PubMed  Google Scholar 

  48. Luft VC, Beghetto MG, de Mello ED, Polanczyk CA. Role of enteral nutrition in the incidence of diarrhea among hospitalized adult patients. Nutrition. 2008;24(6):528–35.

    Article  PubMed  Google Scholar 

  49. Whelan K, Schneider SM. Mechanisms, prevention, and management of diarrhea in enteral nutrition. Curr Opin Gastroenterol. 2011;27(2):152–9.

    Article  PubMed  Google Scholar 

  50. McIvor AC, Meguid MM, Curtas S, Warren J, Kaplan DS. Intestinal obstruction from cecal bezoar; a complication of fiber-containing tube feedings. Nutrition. 1990;6(1):115–7.

    CAS  PubMed  Google Scholar 

  51. Scaife CL, Saffle JR, Morris SE. Intestinal obstruction secondary to enteral feedings in burn trauma patients. J Trauma. 1999;47(5):859–63.

    Article  CAS  PubMed  Google Scholar 

  52. Cangelosi MJ, Auerbach HR, Cohen JT. A clinical and economic evaluation of enteral nutrition. Curr Med Res Opin. 2011;27(2):413–22.

    Article  PubMed  Google Scholar 

  53. Simpson F, Doig GS. Parenteral vs. enteral nutrition in the critically ill patient: a meta-analysis of trials using the intention to treat principle. Intensive Care Med. 2005;31(1): 12–23.

    Article  PubMed  Google Scholar 

  54. Doig GS, Simpson F, Sweetman EA, Finfer SR, Cooper DJ, Heighes PT, et al. Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial. JAMA. 2013;309(20):2130–8.

    Article  CAS  PubMed  Google Scholar 

  55. Casaer MP, Mesotten D, Hermans G, Wouters PJ, Schetz M, Meyfroidt G, et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med. 2011;365(6):506–17. doi:10.1056/NEJMoa1102662.

    Article  CAS  PubMed  Google Scholar 

  56. Binnekade JM, Tepaske R, Bruynzeel P, Mathus-Vliegen EM, de Hann RJ. Daily enteral feeding practice on the ICU: attainment of goals and interfering factors. Crit Care. 2005;9(3):R218–25.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  57. Martins JR, Shiroma GM, Horie LM, Logullo L, Silva Mde L, Waitzberg DL. Factors leading to discrepancies between prescription and intake of enteral nutrition therapy in hospitalized patients. Nutrition. 2012;28(9):864–7.

    Article  PubMed  Google Scholar 

  58. Kutsogiannis J, Alberda C, Gramlich L, Cahill NE, Wang M, Day AG, et al. Early use of supplemental parenteral nutrition in critically ill patients: results of an international multicenter observational study. Crit Care Med. 2011;39(12):2691–9.

    CAS  PubMed  Google Scholar 

  59. Mirtallo J, Canada T, Johnson D, Kumpf V, Petersen C, Sacks G, et al. Safe practices for parenteral nutrition task force for the revision of safe practices for parenteral nutrition. JPEN J Parenter Enteral Nutr. 2004;28:S39.

    Article  PubMed  Google Scholar 

  60. Kritchevsky SB, Braun BI, Kusek L, Wong ES, Solomon SL, Parry MF, et al. The impact of hospital practice on central venous catheter associated bloodstream infection rates at the patient and unit level: a multicenter study. Am J Med Qual. 2008;23(1):24–38.

    Article  PubMed  Google Scholar 

  61. Yang SP, Chen YY, Hsu HS, Wang FD, Chen LY, Fung CP. A risk factor analysis of healthcare-associated fungal infections in an intensive care unit: a retrospective cohort study. BMC Infect Dis. 2013;13:10.

    Article  PubMed Central  PubMed  Google Scholar 

  62. Pronovost P, Needham D, Berenholtz S, Sinopoli D, Chu H, Cosgrove S, et al. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med. 2006;355(26):2725–32.

    Article  CAS  PubMed  Google Scholar 

  63. Dimick JB, Swoboda S, Talamini MA, Pelz RK, Hendrix CW, Lipsett PA. Risk of colonization of central venous catheters: catheters for total parenteral nutrition vs other catheters. Am J Crit Care. 2003;12(4):328–35.

    PubMed  Google Scholar 

  64. Schnitker MA, Mattman PE, Bliss TL. A clinical study of malnutrition in Japanese prisoners of war. Ann Intern Med. 1951;35:69–96.

    Article  CAS  PubMed  Google Scholar 

  65. Afzal NA, Addai S, Fagbemi A, Murch S, Thomson M, Heuschkel R. Refeeding syndrome with enteral nutrition in children: a case report, literature review and clinical guidelines. Clin Nutr. 2002;21:515–20.

    Article  CAS  PubMed  Google Scholar 

  66. Marik PE, Bedigan MK. Refeeding hypophosphatemia in an intensive care unit: a prospective study. Arch Surg. 1996;131:1043–7.

    Article  CAS  PubMed  Google Scholar 

  67. Stanga Z, Brunner A, Leuenberger M, Grimble RF, Shenkin A, Allison SP, et al. Nutrition in clinical practice-the refeeding syndrome: illustrative cases and guidelines for prevention and treatment. Eur J Clin Nutr. 2008;62(6):687–94.

    Article  CAS  PubMed  Google Scholar 

  68. Crook MA, Hally V, Panteli JV. The importance of the refeeding syndrome. Nutrition. 2001;17:632–7.

    Article  CAS  PubMed  Google Scholar 

  69. Marinella MA. The refeeding syndrome and hypophosphatemia. Nutr Rev. 2003;61(9): 320–3.

    Article  PubMed  Google Scholar 

  70. Kohn MR, Golden NH, Shenker IR. Cardiac arrest and delirium: presentations of the refeeding syndrome in severely malnourished adolescents with anorexia nervosa. J Adolesc Health. 1998;22:239–43.

    Article  CAS  PubMed  Google Scholar 

  71. Gustavsson CG, Eriksson L. Acute respiratory failure in anorexia nervosa with hypophosphatemia. J Intern Med. 1989;225:63–4.

    Article  CAS  PubMed  Google Scholar 

  72. Liu PY, Jeng CY. Severe hypophosphatemia in a patient with diabetic ketoacidosis and acute respiratory failure. J Chin Med Assoc. 2004;67:355–9.

    PubMed  Google Scholar 

  73. Mehanna H, Nankivell PC, Moledina J, Travis J. Refeeding syndrome – awareness, prevention and management. Head Neck Oncol. 2009;1(1):4.

    Article  PubMed Central  PubMed  Google Scholar 

  74. Falciglia M, Freyberg RW, Almenoff PL, D'Alessio DA, Render ML. Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis. Crit Care Med. 2009;37(12):3001–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  75. Lee H, Koh SO, Park MS. Higher dextrose delivery via TPN related to the development of hyperglycemia in non-diabetic critically ill patients. Nutr Res Pract. 2011;5(5):450–4.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  76. Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001;345(19):1359–67.

    Article  PubMed  Google Scholar 

  77. Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, et al. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006;354(5):449–61.

    Article  PubMed  Google Scholar 

  78. NICE-SUGAR Study Investigators, Finfer S, Chittock DR, Su SY, Blair D, Foster D, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360(13):1283–97.

    Article  PubMed  Google Scholar 

  79. Egi M, Finfer S, Bellomo R. Glycemic control in the ICU. Chest. 2011;140(1):212–20.

    Article  PubMed  Google Scholar 

  80. Lacherade JC, Jacqueminet S, Preiser JC. An overview of hypoglycemia in the critically ill. J Diabetes Sci Technol. 2009;3(6):1242–9.

    Article  PubMed Central  PubMed  Google Scholar 

  81. NICE-SUGAR Study Investigators, Finfer S, Liu B, Chittock DR, Norton R, Myburgh JA, et al. Hypoglycemia and risk of death in critically ill patients. N Engl J Med. 2012;367(12):1108–18.

    Article  PubMed  Google Scholar 

  82. Krinsley JS, Grover A. Severe hypoglycemia in critically ill patients: risk factors and outcomes. Crit Care Med. 2007;35(10):2262–7.

    Article  PubMed  Google Scholar 

  83. Leite HP, de Lima LF, de Oliveira Iglesias SB, Pacheco JC, de Carvalho WB. Malnutrition may worsen the prognosis of critically ill children with hyperglycemia and hypoglycemia. JPEN J Parenter Enteral Nutr. 2013;37(3):335–41.

    Article  PubMed  Google Scholar 

  84. Critchell CD, Savarese V, Callahan A, Aboud C, Jabbour S, Marik P. Accuracy of bedside capillary blood glucose measurements in critically ill patients. Intensive Care Med. 2007;33(12):2079–84.

    Article  CAS  PubMed  Google Scholar 

  85. Nayak B, Burman K. Thyrotoxicosis and thyroid storm. Endocrinol Metab Clin North Am. 2006;35(4):663–86. vii.

    Article  CAS  PubMed  Google Scholar 

  86. Chong HW, See KC, Phua J. Thyroid storm with multiorgan failure. Thyroid. 2010;20(3): 333–6.

    Article  PubMed  Google Scholar 

  87. Bello G, Ceaichisciuc I, Silva S, Antonelli M. The role of thyroid dysfunction in the critically ill: a review of the literature. Minerva Anestesiol. 2010;76(11):919–28.

    CAS  PubMed  Google Scholar 

  88. Ringel MD. Management of hypothyroidism and hyperthyroidism in the intensive care unit. Crit Care Clin. 2001;17(1):59–74.

    Article  CAS  PubMed  Google Scholar 

  89. Bajwa SJ, Jindal R. Endocrine emergencies in critically ill patients: challenges in diagnosis and management. Indian J Endocrinol Metab. 2012;16(5):722–7.

    Article  PubMed Central  PubMed  Google Scholar 

  90. Wartofsky L. Myxedema coma. Endocrinol Metab Clin North Am. 2006;35(4):687–98. vii–viii.

    Article  CAS  PubMed  Google Scholar 

  91. Klubo-Gwiezdzinska J, Wartofsky L. Thyroid emergencies. Med Clin North Am. 2012;96(2): 385–403.

    Article  PubMed  Google Scholar 

  92. Rodríguez I, Fluiters E, Pérez-Méndez LF, Luna R, Páramo C, García-Mayor RV. Factors associated with mortality of patients with myxoedema coma: prospective study in 11 cases treated in a single institution. J Endocrinol. 2004;180(2):347–50.

    Article  PubMed  Google Scholar 

  93. Marik PE. Mechanisms and clinical consequences of critical illness associated adrenal insufficiency. Curr Opin Crit Care. 2007;13(4):363–9.

    Article  PubMed  Google Scholar 

  94. Bouachour G, Tirot P, Gouello JP, Mathieu E, Vincent JF, Alquier P. Adrenocortical function during septic shock. Intensive Care Med. 1995;21(1):57–62.

    Article  CAS  PubMed  Google Scholar 

  95. Annane D, Bellissant E, Bollaert PE, Briegel J, Confalonieri M, De Gaudio R, et al. Corticosteroids in the treatment of severe sepsis and septic shock in adults: a systematic review. JAMA. 2009;301(22):2362.

    Article  CAS  PubMed  Google Scholar 

  96. Sligl WI, Milner Jr DA, Sundar S, Mphatswe W, Majumdar SR. Safety and efficacy of corticosteroids for the treatment of septic shock: a systematic review and meta-analysis. Clin Infect Dis. 2009;49(1):93–101.

    Article  CAS  PubMed  Google Scholar 

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Slattery, E., Kim, D.W., Seres, D.S. (2014). Nutritional and Endocrinologic Complications. In: Richards, J., Stapleton, R. (eds) Non-Pulmonary Complications of Critical Care. Respiratory Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0873-8_7

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