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Epstein–Barr Virus

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Cancers in People with HIV and AIDS

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Abstract

There are more than one hundred viruses in the herpesvirus family, which is divided into three subfamilies, alpha, beta, and gamma, based on the genome structure and biological behavior of the viruses. Epstein–Barr virus (EBV) is one of the eight herpesviruses currently known to infect humans and is a member of the gammaherpesvirus subfamily, genus lymphocrytovirus. Like all herpesviruses it can establish latent infections and persist for the lifetime of the host. In some individuals it behaves more as a commensal than a pathogen, while in others it can cause significant and even life-threatening disease. EBV is the cause of or contributing factor to the development of a number of HIV-associated cancers, including nearly all cases of central nervous system lymphoma and plasmablastic lymphoma, as well as a high percentage of other non-Hodgkin lymphomas and Hodgkin lymphomas.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Center for Molecular and Tumor Virology and Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA, USA

    Lindsey Hutt-Fletcher

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  1. Lindsey Hutt-Fletcher
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Correspondence to Lindsey Hutt-Fletcher .

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Editors and Affiliations

  1. National Cancer Institute HIV/AIDS Malignancy Branch, National Institutes of Health, Bethesda, Maryland, USA

    Robert Yarchoan

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Hutt-Fletcher, L. (2014). Epstein–Barr Virus. In: Yarchoan, R. (eds) Cancers in People with HIV and AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0859-2_6

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