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AIDS-Related Primary Central Nervous System Lymphoma

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Cancers in People with HIV and AIDS

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Abstract

Primary central nervous system lymphoma (PCNSL) is a rare extra-nodal B-cell non-Hodgkin lymphoma, which arises in the brain, spinal cord, meninges, or eyes. In individuals infected with HIV, PCNSL occurs with advanced immunosuppression and low CD4 T-cell count. It is considered an AIDS-defining malignancy. Unlike PCNSL in immune-competent hosts, AIDS-related PCNSL (AR-PCNSL) is almost exclusively caused by a cancer-causing herpesvirus, Epstein–Barr Virus (EBV, also known as human herpesvirus-4). While PCNSL in immune-competent patients and AR-PCNSL have pathologic and clinical overlap, AR-PCNSL is distinguished by its strong association with immunosuppression and viral etiology.

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Authors and Affiliations

  1. Medical Oncology Branch, Center for Cancer Research, NCI, Bethesda, MD, USA

    Jan Davidson-Moncada

  2. HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Thomas S. Uldrick

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Correspondence to Thomas S. Uldrick .

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  1. National Cancer Institute HIV/AIDS Malignancy Branch, National Institutes of Health, Bethesda, Maryland, USA

    Robert Yarchoan

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Davidson-Moncada, J., Uldrick, T.S. (2014). AIDS-Related Primary Central Nervous System Lymphoma. In: Yarchoan, R. (eds) Cancers in People with HIV and AIDS. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0859-2_15

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