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Bladder Dysfunction in the Adult pp 265–273Cite as

Tissue Engineering for Neurogenic Bladder

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Part of the book series: Current Clinical Urology ((CCU))

Abstract

Failure to store urine due to a neurologic condition or insult can be addressed with multiple modalities. Recently, the role and variety of pharmacologic interventions, neuromodulation, and intradetrusor onabotulinumtoxinA injection have increased. Augmentation cystoplasty retains a place in the treatment algorithm; however, its role has seemingly diminished owing to the morbidity incurred with the use of enteric segments. The chief concern is that these tissues are not created for, and thus are not optimal for, urinary storage. The introduction of tissue engineering strategies by incorporating scaffolds and cell cultures has the potential to remediate the deficiencies seen in enteric segments. Theoretically, this technology may also optimize the bladder’s ability to regenerate and restore its original structure and function. The goal of this chapter is to focus on the advantages and disadvantages of each approach to tissue engineering for the bladder and summarize the key details detailing the progress of the field.

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Authors and Affiliations

  1. Department of Urology, LSU Health—Shreveport, Shreveport, LA, USA

    Alex Gomelsky M.D.

  2. Department of Urologic Surgery, Vanderbilt University Medical Center, A1302 Medical Center North, Nashville, TN, 37232-2765, USA

    Roger R. Dmochowski M.D., M.M.H.C.

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  1. Alex Gomelsky M.D.
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  2. Roger R. Dmochowski M.D., M.M.H.C.
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Corresponding author

Correspondence to Roger R. Dmochowski M.D., M.M.H.C. .

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Editors and Affiliations

  1. Perelman School of Medicine, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA

    Alan J. Wein

  2. Aarhus University, AIAS, Aarhus Institute of Advanced Studies, Aarhus, Denmark

    Karl-Erik Andersson

  3. Urological Institute, University of Bristol and Bristol, Bristol, United Kingdom

    Marcus J. Drake

  4. Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA

    Roger R. Dmochowski

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Gomelsky, A., Dmochowski, R.R. (2014). Tissue Engineering for Neurogenic Bladder. In: Wein, A., Andersson, KE., Drake, M., Dmochowski, R. (eds) Bladder Dysfunction in the Adult. Current Clinical Urology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0853-0_19

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  • DOI: https://doi.org/10.1007/978-1-4939-0853-0_19

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