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Age-Specific Difference in Pulmonary Cellular Injury and Mitochondrial Damage

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Mitochondrial Function in Lung Health and Disease

Part of the book series: Respiratory Medicine ((RM,volume 15))

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Abstract

The impact of lung-targeted toxicants on the respiratory system of developing and aging animals is not well defined, let alone the role that mitochondria may play in the cascade of factors involved in cellular injury. Environmentally induced pulmonary cell injury is often due to exposure to bioactivated toxicants or oxidant gases. The major defense mechanisms against these insults are the antioxidant and xenobiotic-metabolizing enzymes. The age-specific expression of these enzymes and their roles in protecting the lung from specific toxicants is discussed as well as the interrelationship with mitochondrial function. A review of the literature reveals evidence of the mitochondrial involvement in cellular injury during lung development and aging. Whether the alterations of mitochondria are critical early steps in lung injury or an outcome of a cascade of processes during lung development and aging is not clear at this time.

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Authors and Affiliations

  1. Department of Medical, Cystic Fibrosis Foundation, Bethesda, MD, USA

    Katherine L. Tuggle PhD

  2. Department of Environmental Health Sciences, University of Alabama at Birmingham, 1665 University Blvd., 530 Ryals Public Health Building, Birmingham, AL, 35294, USA

    Michelle V. Fanucchi PhD

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  1. Katherine L. Tuggle PhD
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  2. Michelle V. Fanucchi PhD
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Correspondence to Michelle V. Fanucchi PhD .

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  1. Department of Pharmaology and Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

    Viswanathan Natarajan

  2. Division of Allergy, Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, College of Medicine, Ohio State University Wexner, Medical Center, Columbus, Ohio, USA

    Narasimham L. Parinandi

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Tuggle, K.L., Fanucchi, M.V. (2014). Age-Specific Difference in Pulmonary Cellular Injury and Mitochondrial Damage. In: Natarajan, V., Parinandi, N. (eds) Mitochondrial Function in Lung Health and Disease. Respiratory Medicine, vol 15. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0829-5_9

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