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Pulmonary Manifestations of Primary Sjögren’s Syndrome

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Pulmonary Manifestations of Rheumatic Disease

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Abstract

Sjögren’s syndrome (SS) is a chronic systemic inflammatory syndrome whose hallmark is exocrine gland dysfunction due to lymphocytic infiltration. Its etiology is unknown. Although the most common symptoms are dryness of the eyes and mouth, any organ in the body may be affected during the disease course. When it occurs by itself, it is called primary Sjögren’s syndrome (pSS); if it occurs in association with another systemic autoimmune disease (e.g., rheumatoid arthritis, systemic lupus erythematosus, or systemic sclerosis) it is called secondary Sjögren’s syndrome. A diagnosis is established based on a combination of signs, symptoms, and autoantibodies. Pulmonary involvement is common and may present prior to development of sicca symptoms or autoantibodies. Studies of novel therapeutic agents are needed.

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Authors and Affiliations

  1. Department of Pulmonary, Allergy and Critical Care Medicine, University of Alabama Birmingham, 1900 University Boulevard, THT 433A, Birmingham, AL, USA

    Tracy R. Luckhardt M.D., M.S.

  2. Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, 510 20th Street South, Faculty Office Tower 844, Birmingham, AL, 35294, USA

    Barri J. Fessler M.D., M.S.P.H.

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  1. Tracy R. Luckhardt M.D., M.S.
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Correspondence to Tracy R. Luckhardt M.D., M.S. .

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Editors and Affiliations

  1. Harvard Medical School, Department of Medicine, Division of Rheumatology Brigham and Women’s Hospital, Boston, Massachusetts, USA

    Paul F. Dellaripa

  2. Division of Rheumatology, Autoimmune and Interstitial Lung Disease Program, Department of Medicine, National Jewish Health, Denver, Colorado, USA

    Aryeh Fischer

  3. Department of Internal Medicine, Division of Pulmonary/Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA

    Kevin R. Flaherty

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Luckhardt, T.R., Fessler, B.J. (2014). Pulmonary Manifestations of Primary Sjögren’s Syndrome. In: Dellaripa, P., Fischer, A., Flaherty, K. (eds) Pulmonary Manifestations of Rheumatic Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0770-0_8

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