Rapid Diagnostic Tests for Oxidative Stress Status

Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)


Within the field of free radicals in biology and medicine, there is steadily increasing evidence suggesting the general importance of oxidative stress and related inflammation disorders to human health. There is also an increasing need to translate this knowledge into practical applications for the human population. However, many problems currently need to be solved in the development of the oxidative stress profile for clinical use.

In this chapter, the importance of assessing oxidative stress in order to understand the pathophysiology of various disorders in children is described, followed by an introduction of the recent advances in an easy, rapid, specific, and sensitive diagnostic assay of oxidative stress, i.e., point-of-care testing, using the automatic analyzers FRAS4 (Free Radical Analytical System 4; Diacron International srl., Grosseto, Italy) and ICR-001 (Techno Medica Co., Ltd., Yokohama, Japan). The former was designed for successive measurement of the blood levels of reactive oxygen species and the biological antioxidant potential, while the latter was exclusively developed for the assessment of urinary concentrations of 8-oxo-7,8-dihydro-2′-deoxyguanosine, a well-known biomarker for oxidative DNA damage.


Reactive Oxygen Species Kawasaki Disease Rapid Diagnostic Test Oxidative Stress Index Ferric Chloride Solution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.







Biological antioxidant potential


Derivatives of reactive oxygen metabolites


Enzyme-linked immunosorbent assay


Free radical analytical system 4


Idiopathic nephrotic syndrome


Intravenous immunoglobulin therapy


Kawasaki disease


Myopathy encephalopathy, lactic acidosis, and stroke-like episodes


Oxidative stress


Oxidative stress index


Point-of-care testing


Reactive oxygen species



This study was partly funded by grants from the Mami Mizutani Foundation and the Human Resource Chair for Neonatologists funded by Izumi-Ohtsu City, Osaka, Japan and by the Chair for Children with Developmental Disorders funded by Nabari City, Mie, Japan.


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Copyright information

© Springer Science+Business Media, LLC 2014

Authors and Affiliations

  1. 1.Department of PediatricsKansai Medical UniversityHirakata-shi, OsakaJapan

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