Myositis and Pregnancy

  • Stephen J. Di Martino


The idiopathic inflammatory myopathies (IIM) are rare autoimmune disorders characterized predominantly by autoimmune inflammation within skeletal muscle with resulting clinical weakness. Pregnancy in myositis patients is rare and incompletely understood. Systematic review of myositis pregnancy reports suggests that disease activity during pregnancy (even when subclinical) may be associated with adverse pregnancy outcome. Massive deposition of fibrin in the placenta has been described in several myositis patients. Treatment during pregnancy, usually corticosteroid, appears to be associated with greater likelihood of live birth. IVIG has been used successfully and may be an effective alternative to high-dose corticosteroids.


Neonatal Death Pregnancy Loss Inclusion Body Myositis Inflammatory Myopathy Idiopathic Inflammatory Myopathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Division of RheumatologyHospital for Special SurgeryNew YorkUSA

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