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Ginkobiloba Extract Improves Working Memory Performance in Middle-Aged Women: Role of Asymmetry of Prefrontal Cortex Activity During a Working Memory Task

  • Kaoru Sakatani
  • Masahiro Tanida
  • Naoyasu Hirao
  • Naohiro Takemura
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 812)

Abstract

In order to clarify the mechanism through which extract of Ginkgo biloba leaves (EGb) improves cognitive function, we examined the effects of EGb on cerebral blood oxygenation in the prefrontal cortex (PFC) and on performance during a working memory task, using near-infrared spectrometry (NIRS). First, we evaluated differences in behavioral performance of the Sternberg working memory test (ST) and in the activation pattern of the PFC during ST between 15 young and 19 middle-aged healthy women. Then, we examined the effect of EGb (120 mg/day for 6 weeks) on ST performance and PFC activation pattern in the middle-aged group. The middle-aged group exhibited a longer reaction time (RT) in ST than the young group and showed a different PFC activation pattern during ST, i.e., the middle-aged group showed bilateral activation while the young group showed right-dominant activation. In the middle-aged group, administration of EGb for 6 weeks shortened the RT of ST and changed the PFC activation pattern to right-dominant, like that in the young group. The results indicate the PFC plays a role in the physiological cognitive function-enhancing effect of EGb. EGb might improve working memory function in middle-aged individuals by counteracting the occurrence of aging-related hemispheric asymmetry reduction.

Keywords

Ginkobiloba Near-infrared spectroscopy Prefrontal cortex Cerebral blood oxygenation Sternberg working memory test Reaction time 

Notes

Acknowledgements

This research was supported in part by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Sciences and Technology of Japan (B23300247), and grants from Alpha Electron Co., Ltd. (Fukushima, Japan) and Iing Co., Ltd. (Tokyo, Japan).

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Copyright information

© Springer Science+Business Media, LLC 2014

Authors and Affiliations

  • Kaoru Sakatani
    • 1
    • 2
  • Masahiro Tanida
    • 3
  • Naoyasu Hirao
    • 3
  • Naohiro Takemura
    • 4
  1. 1.Laboratory of Integrative Biomedical Engineering, Department of Electrical and Electronics Engineering, College of EngineeringNihon UniversityKoriyamaJapan
  2. 2.Department of Neurological SurgeryNihon University School of MedicineTokyoJapan
  3. 3.Shiseido Research CenterYokohamaJapan
  4. 4.Laboratory of Integrative Biomedical Engineering, Department of Electrical and Electronics Engineering, College of EngineeringNihon UniversityKoriyamaJapan

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