Optical Imaging of Brain Activation in Gambian Infants

  • Marie D. Papademetriou
  • S. Lloyd-Fox
  • N. L. Everdell
  • M. K. Darboe
  • S. E. Moore
  • A. M. Prentice
  • C. E. Elwell
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 812)

Abstract

We used optical topography (OT) to investigate cognitive function in infants in rural Gambia. Images of changes in oxyhaemoglobin and deoxyhaemoglobin concentrations were reconstructed using a multispectral algorithm which uses the finite element method (FEM) to model the propagation of light through scattering tissue using the diffusion equation. High quality OT data enabled us to reconstruct images with robust representation of haemodynamic changes. OT is a feasible neuroimage technology for this resource-poor setting.

Keywords

Brain development Infant undernutrition Functional near infrared spectroscopy 

Notes

Acknowledgments

This work is supported by a Grand Challenges Exploration Phase 1 grant from the Bill and Melinda Gates Foundation, and hosted by MRC Keneba (MC-A760-5QX00). We are grateful to the field workers at MRC Keneba, Lamin Sanyang, Saikou Drammeh and Ousman Kambi, for their help with data collection.

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Copyright information

© Springer Science+Business Media, LLC 2014

Authors and Affiliations

  • Marie D. Papademetriou
    • 1
  • S. Lloyd-Fox
    • 2
  • N. L. Everdell
    • 1
  • M. K. Darboe
    • 3
  • S. E. Moore
    • 3
    • 4
  • A. M. Prentice
    • 3
    • 4
  • C. E. Elwell
    • 1
  1. 1.Department of Medical Physics and BioengineeringUniversity College LondonLondonUK
  2. 2.Centre for Brain and Cognitive Development, BirkbeckUniversity of LondonLondonUK
  3. 3.MRC International Nutrition Group, MRC KenebaKenebaThe Gambia
  4. 4.MRC International Nutrition Group, London School of Hygiene and Tropical MedicineLondonUK

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