Ischemic Pretreatment Delays Ischemic Brain Vasospasm Injury in Gerbils

Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 812)


Three experiments were conducted for the present study. First, to elucidate the mechanism and functional significance underlying ischemic vasoconstriction, we investigated the relationship between arteriolar constriction and tissue energy metabolism during bilateral common carotid artery occlusion in gerbils. Second, to identify differences in the postischemic recovery of physiologic parameters between short and prolonged brain ischemia, we measured changes in regional cerebral blood flow, microvessel diameter, brain temperature, and electrophysiologic response. Third, to explore the physiological mechanism of ischemic tolerance, we studied vascular response and intracerebral oxygenation states after acute global ischemia with and without pretreatment by mild ischemic stress. Here, we identify one of the physiologic mechanisms of the ischemic tolerance caused by brief ischemic pretreatment.


Global ischemia Cerebral blood flow Brain temperature Reperfusion injury Ischemic tolerance 



The authors thank Dr. Hirokazu Ueda, Dr. Ji-Yao Li, Dr. Takehiko Yanagihara, Dr. Goro Tajima, Dr. Hiroshi Tanaka, and Dr. Hisashi Sugimoto. This study was supported in part by grants-in-aid from the Ministry of Education, Science and Culture of Japan.


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    Li JY, Ueda H, Seiyama A et al (2007) Ischemic vasoconstriction and tissue energy metabolism during global cerebral ischemia in gerbils. J Neurotrauma 24:547–558CrossRefPubMedGoogle Scholar
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    Tajima G, Shiozaki T, Seiyama A et al (2007) Mismatch recovery of regional cerebral blood flow and brain temperature during reperfusion after prolonged brain ischemia in gerbils. J Trauma 62:36–43CrossRefPubMedGoogle Scholar
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    Li JY, Ueda H, Seiyama A et al (1997) A near-infrared spectroscopic study of cerebral ischemia and ischemic tolerance in gerbils. Stroke 28:1451–1456CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2014

Authors and Affiliations

  • Akitoshi Seiyama
    • 1
  • Nao Yoshikawa
    • 1
  • Yukio Imamura
    • 1
  1. 1.Division of Medical Devices for Diagnoses, Human Health Sciences, Graduate School of MedicineKyoto UniversityKyotoJapan

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