Ischemic Pretreatment Delays Ischemic Brain Vasospasm Injury in Gerbils
Three experiments were conducted for the present study. First, to elucidate the mechanism and functional significance underlying ischemic vasoconstriction, we investigated the relationship between arteriolar constriction and tissue energy metabolism during bilateral common carotid artery occlusion in gerbils. Second, to identify differences in the postischemic recovery of physiologic parameters between short and prolonged brain ischemia, we measured changes in regional cerebral blood flow, microvessel diameter, brain temperature, and electrophysiologic response. Third, to explore the physiological mechanism of ischemic tolerance, we studied vascular response and intracerebral oxygenation states after acute global ischemia with and without pretreatment by mild ischemic stress. Here, we identify one of the physiologic mechanisms of the ischemic tolerance caused by brief ischemic pretreatment.
KeywordsGlobal ischemia Cerebral blood flow Brain temperature Reperfusion injury Ischemic tolerance
The authors thank Dr. Hirokazu Ueda, Dr. Ji-Yao Li, Dr. Takehiko Yanagihara, Dr. Goro Tajima, Dr. Hiroshi Tanaka, and Dr. Hisashi Sugimoto. This study was supported in part by grants-in-aid from the Ministry of Education, Science and Culture of Japan.