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Physiological Mechanism of Increase in Deoxy-hemoglobin Concentration During Neuronal Activation in Patients with Cerebral Ischemia: A Simulation Study with the Balloon Model

  • Naohiro Takemura
  • Kaoru Sakatani
  • Atsuo Yoshino
  • Teruyasu Hirayama
  • Yoichi Katayama
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 812)

Abstract

Patients with cerebral ischemia or brain tumor have been reported to exhibit an increase of deoxygenated hemoglobin (deoxy-Hb) together with an increase of oxygenated hemoglobin (oxy-Hb). However, the physiological mechanisms underlying this hemodynamic response pattern are unclear. In this study, we performed a simulation using the balloon model (Buxton et al., Magn Reson Med 39:855–864, 1998). We hypothesized that the oxygen extraction rate during the rest period (E0) in the patients is larger than in normal subjects, because the cerebral blood flow and the speed at which the blood passes through the brain tissues are lower in the patients. The simulation result showed an increase of deoxy-Hb as well as oxy-Hb, especially when E0 is extremely high. Thus, the results of our simulation suggest that the increase of deoxy-Hb during activation in patients with ischemia or brain tumor is caused by an increased oxygen extraction rate at rest, compared with that of healthy adults.

Keywords

Cerebral blood oxygenation Ischemia Near-infrared spectroscopy Balloon model 

Notes

Acknowledgments

This research was supported in part by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Sciences and Technology of Japan (B23300247), and grants from Alpha Electron Co., Ltd. (Fukushima, Japan) and Iing Co., Ltd. (Tokyo, Japan).

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Copyright information

© Springer Science+Business Media, LLC 2014

Authors and Affiliations

  • Naohiro Takemura
    • 1
  • Kaoru Sakatani
    • 1
    • 2
  • Atsuo Yoshino
    • 3
  • Teruyasu Hirayama
    • 3
  • Yoichi Katayama
    • 3
  1. 1.Laboratory of Integrative Biomedical Engineering, Department of Electrical and Electronics Engineering, College of EngineeringNihon UniversityKoriyamaJapan
  2. 2.Department of Neurological SurgeryNihon University School of MedicineTokyoJapan
  3. 3.Division of Neurosurgery, Department of Neurological SurgeryNihon University School of MedicineItabashi-ku, TokyoJapan

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