Advertisement

Influence of the Maternal Use of Labetalol on the Neurogenic Mechanism for Cerebral Autoregulation Assessed by Means of NIRS

  • Alexander Caicedo
  • Carolina Varon
  • Liesbeth Thewissen
  • Gunnar Naulaers
  • Petra Lemmers
  • Frank Van Bel
  • Sabine Van Huffel
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 812)

Abstract

Labetalol is a drug used in the treatment of hypertensive disorders of pregnancy (HDP). In a previous study we investigated the influence of the maternal use of labetalol on the cerebral autoregulation (CA) mechanism of neonates. In that study, we found that labetalol induces impaired CA during the first day of life, with CA returning to a normal status by the third day after birth. This effect was hypothesized to be caused by labetalol-induced vasodilation. However, no strong evidence for this claim was found. In this study we aim to find stronger evidence for the vasodilation effect caused by labetalol, by investigating its effect on the neurogenic mechanism (NM) involved in CA. The status of the NM was assessed by means of transfer function analysis between the low frequency content of the autonomic control activity (LFA), obtained by processing of the heart rate (HR), and the regional cerebral oxygen saturation (rScO2). We found that neonates from mothers treated with labetalol presented a lower LFA and an impaired NM response during the first day of life, with values returning to normal by the end of the third day. These results reflect a vasodilation effect caused by labetalol, and indicate that the impaired CA observed in the previous study is caused by vasodilation.

Keywords

Labetalol Hypertensive disorders of pregnancy Vasodilation effect Neurogenic mechanism Cerebral autoregulation 

Notes

Acknowledgments

Research supported by a postdoctoral mandate of the KU Leuven (BOF-KU Leuven) and: Research Council KUL: GOA MaNet, PFV/10/002 (OPTEC), IDO 08/013 Autism, several PhD/postdoc & fellow grants. Flemish Government: FWO: PhD/postdoc grants, projects: G.0427.10N (Integrated EEG-fMRI), G.0108.11 (Compressed Sensing) G.0869.12N (Tumor imaging) G.0A5513N (Deep brain stimulation); IWT: TBM070713-Accelero, TBM080658-MRI (EEG-fMRI), TBM110697-NeoGuard, PhD Grants; iMinds 2013; Flanders Care: Demonstratieproject Tele-Rehab III (2012–2014). Belgian Federal Science Policy Office: IUAP P719/(DYSCO, `Dynamical systems, control and optimization', 2012–2017); ESA AO-PGPF-01, PRODEX (CardioControl) C4000103224. EU: RECAP 209G within INTERREG IVB NWE programme, EU HIP Trial FP7-HEALTH/ 2007–2013 (n° 260777), EU MC ITN Transact 2012 # 316679 y carito linda.

References

  1. 1.
    Magee LA, Elran E et al (2000) Risks and benefits of beta-receptor blockers for pregnancy hypertension: overview of the randomized trials. Eur J Obstetr Gynecol Reproduct Biol 88(1):15–26CrossRefGoogle Scholar
  2. 2.
    Haraldsson A, Geven W (1989) Half-life of maternal labetalol in a premature infant. Pharm Week Sci Ed 11(6):229–231CrossRefGoogle Scholar
  3. 3.
    Peng T, Rowley A, Ainslie PN et al (2008) Multivariate system identification for cerebral autoregulation. Ann Biomed Eng 36(2):308–320CrossRefPubMedGoogle Scholar
  4. 4.
    Purkayastha S, Saxena A et al (2012) α1-Adrenergic receptor control of the cerebral vasculature in humans at rest and during exercise. Exp Physiol. doi: 10.1113/expphysiol.2012.066118 PubMedGoogle Scholar
  5. 5.
    Caicedo A and Van Huffel S (2010) Weighted LS-SVM for function estimation applied to artifact removal in biosignal processing. Proceedings of the 32nd annual international conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2010), Buenos Aires, Argentina, August 31–September 4, pp 988–991Google Scholar
  6. 6.
    Pichot V, Gaspoz JM et al (1999) Wavelet transform to quantify heart rate variability and to assess its instantaneous changes. J Appl Physiol 86:1081–1091CrossRefPubMedGoogle Scholar
  7. 7.
    Schaffer L, Burkhardt T et al (2008) Cardiac autonomic balance in small-for-gestational-age neonates. Am J Physiol Heart Circ Physiol 294:H884–H890CrossRefPubMedGoogle Scholar
  8. 8.
    Caicedo A, Thewissen L et al (2013) Effect of the maternal use of labetalol on the cerebral autoregulation in premature infants. Adv Exp Med Biol 789:105–111CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2014

Authors and Affiliations

  • Alexander Caicedo
    • 1
    • 2
  • Carolina Varon
    • 1
    • 2
  • Liesbeth Thewissen
    • 3
  • Gunnar Naulaers
    • 3
  • Petra Lemmers
    • 4
  • Frank Van Bel
    • 4
  • Sabine Van Huffel
    • 1
    • 2
  1. 1.Department of Electrical Engineering (ESAT)STADIUS Center for Dynamical Systems, Signal Processing, and Data Analytics, KU LeuvenHeverlee (Leuven)Belgium
  2. 2.iMinds Medical IT, KU LeuvenLeuvenBelgium
  3. 3.Neonatal Intensive Care UnitUniversity Hospitals Leuven, KU LeuvenLeuvenBelgium
  4. 4.Department of NeonatologyWilhelmina Children’s Hospital, University Medical CenterUtrechtThe Netherlands

Personalised recommendations