EPR Image Based Oxygen Movies for Transient Hypoxia

Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 812)

Abstract

Chronic hypoxia strongly affects the malignant state and resistance to therapy for tumors. Transient hypoxia has been hypothesized, but not proven to be more deleterious. Electron paramagnetic resonance imaging (EPRI) provides non-invasive, quantitative imaging of static pO2 in vivo. Dynamic EPRI produces pO2 movies, enabling non-invasive assessment of in vivo pO2 changes, such as transient hypoxia. Recent developments have been made to enable Dynamic EPRI. Maximally spaced projection sequencing has been implemented to allow for more accurate and versatile acquisition of EPRI data when studying dynamic systems. Principal component analysis filtering has been employed to enhance SNR. Dynamic EPRI studies will provide temporally resolved oxygen movies necessary to perform in vivo studies of physiologically relevant pO2 changes in tumors. These oxygen movies will allow for the localization/quantification of transient hypoxia and will therefore help to disentangle the relationship between chronic and transient hypoxia, in order to better understand their roles in therapeutic optimization and outcome.

Keywords

Dynamic EPRI Oxygen movies PCA Projection acquisition Transient hypoxia 

Notes

Acknowledgments

Supported by NIH grants P41 EB002034 and R01 CA98575.

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Copyright information

© Springer Science+Business Media, LLC 2014

Authors and Affiliations

  • Gage Redler
    • 1
    • 2
  • Boris Epel
    • 1
    • 2
  • Howard J. Halpern
    • 1
    • 2
    • 3
  1. 1.Center for EPR Imaging In Vivo PhysiologyChicagoUSA
  2. 2.Department of Radiation OncologyUniversity of ChicagoChicagoUSA
  3. 3.MC1105, Department of Radiation and Cellular OncologyUniversity of Chicago Medical CenterChicagoUSA

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