What We Learn from In Vivo EPR Oxygen Images

Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 812)


Distributions of oxygen concentration (pO2) are a critical determinant of normal tissue health as well as tumor aggressiveness and response to therapy. A number of studies show the value of normal tissue and tumor tissue oxygenation images and some of these will be discussed here. A strong correlation between tumor hypoxic fraction as measured with electron paramagnetic resonance oxygen imaging and radiation treatment success or failure has been found in two separate cancer types. Oxygen images of the torso of wild type mice show initial reduction of lung, liver, visceral, and muscle pO2 with cyclic halving of fraction of inspired oxygen (FiO2), but variation is blunted over an hour. Spontaneous breast cancers in Mouse Mammary Tumor Viral (MMTV) promoted-polyoma middle T antigen (PyMT) mice with BNIP3, a major factor in promotion of mitochondrial autophagy, knocked out will be compared with wild type animals. Preliminary studies for the BNIP3 knock out animals show extremely low pO2. The wide variety of studies, in which oxygen images can play an integral role, serve to demonstrate the importance of oxygen images.


EPR Oxygen imaging Hypoxia BNIP3 Cancer Microenvironment response 



Supported by NIH grants P41 EB002034 and R01 CA98575.


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Copyright information

© Springer Science+Business Media, LLC 2014

Authors and Affiliations

  • Gage Redler
    • 1
    • 2
  • Boris Epel
    • 1
    • 2
  • Howard J. Halpern
    • 1
    • 2
    • 3
  1. 1.Center for EPR Imaging In Vivo PhysiologyChicagoUSA
  2. 2.Department of Radiation OncologyUniversity of ChicagoChicagoUSA
  3. 3.MC1105, Department of Radiation and Cellular OncologyUniversity of Chicago Medical CenterChicagoUSA

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