Skip to main content
SpringerLink
Log in
Book cover

Stem Cell Banking pp 77–93Cite as

Banking of Pluripotent Stem Cells: Issues and Opportunities from the NIH Perspective

  • Chapter
  • First Online:

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Over the past 15 years, pluripotent stem (PS) cells have changed the face of biomedical research and provided fresh hope for regenerative medicine-based therapies. Successful implementation of PS cell-based therapy will rely on developing an organized plan for identifying appropriate biospecimen donors, obtaining appropriate consent, collecting necessary patient history data, and developing an organized system for storage and delivery of tissue samples and cell lines. This is particularly important as the number of PS cells being generated is large and ever-growing, and the potential for their use in drug discovery and therapy depends on organized, comprehensive systems for generating systematically well-characterized cell lines and cell line panels from which differentiated cells can be generated. In this chapter, we outline the efforts made by the US National Institutes of Health (NIH) to develop a human embryonic stem (hES) cell registry and PS cell banks, efforts we believe will be an integral part of the future of PSC therapy.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Bush GW. The white house, fact sheet on embryonic stem cell research. (http://georgewbush-whitehouse.archives.gov/news/releases/2001/08/20010809-1.html). 9 Aug 2001.

  2. NIH Human Embryonic Stem Cell Registry Under Former President Bush (9 Aug 2001–9 Mar 2009). Stem cell information [World Wide Web site]. Bethesda, MD: National Institutes of Health, U.S. Department of Health and Human Services; 2012. http://stemcells.nih.gov/research/registry/Pages/eligibilitycriteria.aspx. Accessed 05 Nov 2013.

  3. NIH Stem Cell Research Funding, FY 2002–2012. Stem cell information [World Wide Web site]. Bethesda, MD: National Institutes of Health, U.S. Department of Health and Human Services; 2013. http://stemcells.nih.gov/research/funding/pages/Funding.aspx. Accessed 5 Nov 2013.

  4. National Institutes of Health. NIH awards a national stem cell bank and new centers of excellence in translational human stem cell research. Press release from the NIH Office of the Director (http://www.nih.gov/news/pr/oct2005/od-03.htm) 3 Oct 2005.

  5. NIH Human Embryonic Stem Cell Registry. Stem cell information [World Wide Web site]. Bethesda, MS: National Institutes of Health, U.S. Department of Health and Human Services; 2013. http://grants.nih.gov/stem_cells/registry/current.htm. Accessed 5 Nov 2013.

  6. Crook JM, Peura TT, Kravets L, Bosman AG, Buzzard JJ, Home R, et al. The generation of six clinical-grade human embryonic stem cell lines. Cell Stem Cell. 2007;1:490–4.

    Article  CAS  Google Scholar 

  7. Stem Cells and Diseases. Stem cell information [World Wide Web site]. Bethesda, MD: National Institutes of Health, U.S. Department of Health and Human Services; 2012. http://stemcells.nih.gov/info/pages/health.aspx. Accessed 5 Nov 2013.

  8. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663–76.

    Article  CAS  PubMed  Google Scholar 

  9. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131:861–72.

    Article  CAS  PubMed  Google Scholar 

  10. Rao MS, Malik N. Assessing iPSC reprogramming methods for their suitability in translational medicine. J Cell Biochem. 2013;113:3061–8.

    Article  Google Scholar 

  11. Lomax GP, Peckman SR. Stem cell policy exceptionalism: proceed with caution. Stem Cell Rev. 2012;8:299–304.

    Article  PubMed  Google Scholar 

  12. NIH Stem Cell Unit. Stem cell information [World Wide Web site]. Bethesda, MD: National Institutes of Health, U.S. Department of Health and Human Services; 2012. http://stemcells.nih.gov/research/nihresearch/scunit/Pages/Default.aspx. Accessed 5 Nov 2013.

  13. Executive Order 13505, 3 C.F.R. 10667; 2009.

    Google Scholar 

  14. 2009 Guidelines on Human Stem Cell Research. Stem cell information [World Wide Web site]. Bethesda, MD: National Institutes of Health, U.S. Department of Health and Human Services; 2011. http://stemcells.nih.gov/policy/pages/2009guidelines.aspx. Accessed 5 Nov 2013.

  15. Okita K, Yamakawa T, Matsumura Y, Sato Y, Amano N, Watanabe A, et al. An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells. Stem Cells. 2013;31:458–66.

    Article  CAS  PubMed  Google Scholar 

  16. Zhou T, Benda C, Dunzinger S, Huang Y, Ho JC, Yang J, et al. Generation of human induced pluripotent stem cells from urine samples. Nat Protoc. 2012;7:2080–9.

    Article  CAS  PubMed  Google Scholar 

  17. Eisenstein M. Up for grabs. Nat Biotechnol. 2010;28:544–6.

    Article  CAS  PubMed  Google Scholar 

  18. Georgieva BP, Love JM. Human induced pluripotent stem cells: a review of the US patent landscape. Regen Med. 2010;5:581–91.

    Article  PubMed  Google Scholar 

  19. Lowenthal J, Lipnick S, Rao M, Hull SC. Specimen collection for induced pluripotent stem cell research: harmonizing the approach to informed consent. Stem Cells Transl Med. 2012;1:409–21.

    Article  PubMed Central  PubMed  Google Scholar 

  20. Lowenthal J, Hull S. Framing the “Right to Withdraw” in the use of biospecimens for iPSC research. Ethics Biol Eng Med. 2013;4(1):1–14.

    Google Scholar 

  21. Lomax GP, Hull SC, Lowenthal J, Rao M, Isasi R. The DISCUSS project: induced pluripotent stem cell lines from previously collected research biospecimens and informed consent: points to consider. Stem Cells Transl Med. 2013;2:727–30.

    Article  PubMed  Google Scholar 

  22. Rao MS, Collins FS. Steering a new course for stem cell research: NIH’s Intramural Center for Regenerative Medicine. Stem Cells Transl Med. 2012;1:15–7.

    Article  PubMed Central  PubMed  Google Scholar 

  23. Rao M. Public private partnerships: a marriage of necessity. Cell Stem Cell. 2013;12:149–51.

    Article  CAS  PubMed  Google Scholar 

  24. Rao MS. LULL(ed) into complacency: a perspective on licenses and stem cell translational science. Stem Cell Res Ther. 2013;4:98.

    PubMed Central  PubMed  Google Scholar 

  25. Rao M. iPSC Crowdsourcing: a model for obtaining large panels of stem cell lines for screening. Cell Stem Cell. 2013;13:389–91.

    Article  CAS  PubMed  Google Scholar 

  26. Turner M, Leslie S, Martin NG, Peschanski M, Rao M, Taylor CJ, et al. Toward the development of a global induced pluripotent stem cell library. Cell Stem Cell. 2013;13:382–4.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by the NIH Center of Regenerative Medicine, an NIH Common Fund Initiative and the Intramural Research Program of the NIH. The opinions expressed in this article represent the views of the authors and in no way can be construed to reflect the opinion or policy of the NIH, DHHS, or US Federal Government.

Author information

Authors and Affiliations

  1. National Institutes of Health Center for Regenerative Medicine (NIH CRM), NIH, Bethesda, MD, USA

    Anastasia G. Efthymiou & Mahendra Rao

  2. National Institutes of Health Department of Bioethics, Clinical Center, NIH, Bethesda, MD, USA

    Justin Lowenthal

Authors
  1. Anastasia G. Efthymiou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mahendra Rao
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Justin Lowenthal
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anastasia G. Efthymiou .

Editor information

Editors and Affiliations

  1. Division of Women's Health, King's College London School of Medicine, United Kingdom

    Dusko Ilic

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this chapter

Cite this chapter

Efthymiou, A.G., Rao, M., Lowenthal, J. (2014). Banking of Pluripotent Stem Cells: Issues and Opportunities from the NIH Perspective. In: Ilic, D. (eds) Stem Cell Banking. Stem Cell Biology and Regenerative Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0585-0_8

Download citation

Publish with us

Policies and ethics

Search

Navigation