Pathophysiology of Obesity and the Metabolic Syndrome: Rodent Models

  • David Sanchez-Infantes
  • Carrie M. Elks
  • Jacqueline M. StephensEmail author
Part of the Nutrition and Health book series (NH)


Metabolic syndrome (MetS) affects one in three Americans and is a strong predictor of cardiovascular disease risk; therefore, understanding the pathophysiological mechanisms that contribute to MetS is of great priority. While rodent models can only reproduce certain aspects of human diseases, they remain useful tools in our examination of the mechanisms contributing to the development of MetS. This chapter will provide a brief review of some of the more common mouse and rat MetS models. In addition to brief descriptions of the models, the advantages and disadvantages of using each model will be addressed.


Metabolic syndrome Adipocyte Adipose tissue Obesity 


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • David Sanchez-Infantes
    • 1
  • Carrie M. Elks
    • 1
  • Jacqueline M. Stephens
    • 1
    Email author
  1. 1.Department of Adipocyte Biology, Pennington Biomedical Research CenterLouisiana State UniversityBaton RougeUSA

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