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Pharmacotherapy for Obesity

  • Giuseppe DerosaEmail author
  • Pamela Maffioli
Chapter
Part of the Nutrition and Health book series (NH)

Abstract

The current recommendations for the treatment of obese people include increased physical activity and reduced calories intake; when the behavioral approach is not sufficient, a pharmacologic treatment is recommended. In the past years, a number of medications have been approved for the treatment of obesity, but many of them have been withdrawn from the market because of their adverse effects. Actually only orlistat is available for use in Europe, because amphetamines, rimonabant, and sibutramine licenses have been withdrawn due to lack of efficacy leading to an unfavorable benefit/risk ratio linked to amphetamines; psychiatric disorders, especially depression, linked to rimonabant; and an increased risk of nonfatal myocardial infarction or stroke linked to sibutramine.

Recently FDA approved two new drugs for the treatment of obesity: the first one was lorcaserin and the second one was phentermine/topiramate extended-release combination. Both these newly approved drugs seem promising and safe also in type 2 diabetic patients; however, long-term studies are ongoing to evaluate their cardiovascular safety.

Keywords

Amphetamines Exenatide Lorcaserin Obesity Orlistat Phentermine and topiramate extended-release 

Notes

Acknowledgement

The authors certify that they have no affiliation with, or financial involvement in, any organization or entity with a direct financial interest in the subject matter or materials discussed in the manuscript.

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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Internal Medicine and TherapeuticsUniversity of PaviaPaviaItaly

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