Alterations in Phospholipase D During the Development of Myocardial Disease

Part of the Advances in Biochemistry in Health and Disease book series (ABHD, volume 10)


Phospholipase D (PLD) produces phosphatidic acid, which is converted to diacylglycerol (DAG) by phosphatidate phosphohydrolase (PAP). Since both these lipid signaling molecules regulate Ca2+-movements, they also influence cardiac contractile function. In this article, we discuss the importance of PLD in relation to the production of lipid signaling molecules and regulation of cardiac function under various pathophysiological conditions such as ischemic heart disease, diabetic cardiomyopathy, and congestive heart failure. In fact, marked alterations in PLD activities have been reported to occur in ischemic heart, diabetic heart, and failing heart. While the mechanisms of changes in PLD activities in heart disease may be of complex nature, oxidative stress seems to play a critical role in the activation of PLD. From the evidence provided it is suggested that impairment in this phospholipid signal transduction pathway results in cardiac dysfunction during the development of different myocardial diseases.


Phospholipase D Signal transduction Diabetic cardiomyopathy Congestive heart failure Ischemia-reperfusion injury PLD-mediated signal transduction 



Infrastructural support was provided by the St. Boniface Hospital Research Foundation.


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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Asper Clinical Research InstituteSt. Boniface Hospital Research CentreWinnipegCanada
  2. 2.Faculty of Medicine, Institute of Cardiovascular Sciences and Department of PhysiologyUniversity of ManitobaWinnipegCanada

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