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Parathyroid Carcinoma

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Atlas of Endocrine Pathology

Part of the book series: Atlas of Anatomic Pathology ((AAP))

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Abstract

Parathyroid carcinoma accounts for 1 % of hyperparathyroidism cases, affects men and women equally, and occurs over a wide age range, although most patients are in their mid-40s to mid-50s. Symptoms are polyuria, polydipsia, nephrolithiasis, fatigue, nausea, bone disease, and a palpable neck mass. Serum calcium often is markedly elevated (13.2–15.5 mg/dL), as is parathyroid hormone (PTH) and alkaline phosphatase. Most carcinomas are sporadic but may occur in hyperparathyroidism–jaw tumor syndrome (HP-JT) and familial isolated hyperparathyroidism (FIH). FIH, an autosomal dominant disorder associated with HRPT2, MEN1, and a 1.7-Mb region on 2p13.3-14, involves only the parathyroid. HP-JT is an autosomal dominant disorder caused by inactivating mutations of the HRPT2 tumor suppressor gene (1q21-q32). The incidence of parathyroid carcinoma in HJ-PT is 15 %.

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Authors and Affiliations

  1. Mayo Clinic College of Medicine, Rochester, MN, USA

    Lori A. Erickson MD

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  1. Lori A. Erickson MD
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Erickson, L.A. (2014). Parathyroid Carcinoma. In: Atlas of Endocrine Pathology. Atlas of Anatomic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0443-3_17

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  • DOI: https://doi.org/10.1007/978-1-4939-0443-3_17

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-0442-6

  • Online ISBN: 978-1-4939-0443-3

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