Metastases to Thyroid

  • Lori A. Erickson
Part of the Atlas of Anatomic Pathology book series (AAP)


Metastases to the thyroid from tumors of other sites are not uncommon in patients with disseminated cancer, as metastases are identified in approximately 25 % of autopsies in this setting. The most common primary tumors to metastasize to the thyroid are renal cell carcinoma, lung cancer, breast cancer, malignant melanoma, esophageal cancer, and gynecologic malignancies. The tumors may form a single mass or show multifocal disease. Patients may present with a mass, hoarseness, pain, or dysphagia. Squamous cell carcinoma of the head and neck may involve the thyroid secondarily by direct extension. Metastases to the thyroid generally retain the histologic features of the primary tumor, and many are known to have metastatic disease elsewhere at the time of presentation of the thyroid metastasis.


  1. 1.
    Cichon S, et al. Metastases to the thyroid gland: seventeen cases operated on in a single clinical center. Langenbecks Arch Surg. 2006;391(6):581–7.PubMedCrossRefGoogle Scholar
  2. 2.
    Nakhjavani MK, et al. Metastasis to the thyroid gland. A report of 43 cases. Cancer. 1997;79(3):574–8.PubMedCrossRefGoogle Scholar
  3. 3.
    Heffess CS, Wenig BM, Thompson LD. Metastatic renal cell carcinoma to the thyroid gland: a clinicopathologic study of 36 cases. Cancer. 2002;95(9):1869–78.PubMedCrossRefGoogle Scholar
  4. 4.
    Wood K, Vini L, Harmer C. Metastases to the thyroid gland: the Royal Marsden experience. Eur J Surg Oncol. 2004;30(6):583–8.PubMedCrossRefGoogle Scholar
  5. 5.
    Papi G, et al. Metastases to the thyroid gland: prevalence, clinicopathological aspects and prognosis: a 10-year experience. Clin Endocrinol. 2007;66(4):565–71.Google Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Lori A. Erickson
    • 1
  1. 1.Mayo Clinic College of MedicineRochesterUSA

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