Cryostimulation as Adjunct Treatment in Psychiatric Disorders

  • Elżbieta MillerEmail author
Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)


Currently, the use of medications is the standard and most common method of biological treatment in psychiatry. However, sometimes pharmacotherapy does not lead to remission, so research is being carried out into other, non-pharmacological strategies of treatment.

There is a need for developing new therapies such as cryostimulation that can be used as adjunct psychiatric therapy. The mechanisms of action of hypothermic protection are not entirely understood. The response of the human body to cold occurs through the changes in the endocrine, circulatory, nervous–muscular, and immunological systems. Cryostimulation has been found useful in neurological and psychiatric disorders, especially depression. It seems that cryostimulation may be used as adjuvant therapy in the treatment of diseases with oxidative stress background since it improves the antioxidant capacity of organism.

In this study, the physiology and neuroprotection of hypothermia and influence of cryostimulation on oxidative stress in psychiatric disorders especially depression are presented. The effects of cryostimulation in multiple sclerosis depressive patients are shown.


Multiple Sclerosis Multiple Sclerosis Patient Complementary Medicine Hamilton Anxiety Rate Scale Magnetic Seizure Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Adrenocorticotropic hormone


Beck Depression Inventory


Brain derived neurotrophic factor




Corticotropin-releasing hormone




Expanded Disability Status Scale


Glutathione peroxidase


Hamilton anxiety rating scale


Hamilton depression rating scale


Hypothalamic–pituitary–adrenal axis


Insulin-like growth factor




Magnetic resonance image


Multiple sclerosis




Primary-progressive multiple sclerosis


Progressive-relapsing multiple sclerosis


Reactive nitrogen species


Reactive oxygen species


Relapsing-remitting multiple sclerosis


Superoxide dismutase


Secondary-progressive multiple sclerosis


Total antioxidative status


Tumor necrosis factor


Uric acid


Whole-body cryotherapy



I would like to thank all staff of the Department of General Biochemistry at the University of Lodz in Poland, especially Professor Barbara Wachowicz, for support and very useful comments.


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© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Physical MedicineMedical University of LodzLodzPoland
  2. 2.Neurorehabilitation Ward, III General Hospital in LodzLodzPoland

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