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Cryostimulation as Adjunct Treatment in Psychiatric Disorders

  • Elżbieta MillerEmail author
Chapter
Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)

Abstract

Currently, the use of medications is the standard and most common method of biological treatment in psychiatry. However, sometimes pharmacotherapy does not lead to remission, so research is being carried out into other, non-pharmacological strategies of treatment.

There is a need for developing new therapies such as cryostimulation that can be used as adjunct psychiatric therapy. The mechanisms of action of hypothermic protection are not entirely understood. The response of the human body to cold occurs through the changes in the endocrine, circulatory, nervous–muscular, and immunological systems. Cryostimulation has been found useful in neurological and psychiatric disorders, especially depression. It seems that cryostimulation may be used as adjuvant therapy in the treatment of diseases with oxidative stress background since it improves the antioxidant capacity of organism.

In this study, the physiology and neuroprotection of hypothermia and influence of cryostimulation on oxidative stress in psychiatric disorders especially depression are presented. The effects of cryostimulation in multiple sclerosis depressive patients are shown.

Keywords

Multiple Sclerosis Multiple Sclerosis Patient Complementary Medicine Hamilton Anxiety Rate Scale Magnetic Seizure Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

ACTH

Adrenocorticotropic hormone

BDI

Beck Depression Inventory

BDNF

Brain derived neurotrophic factor

CAT

Catalase

CRH

Corticotropin-releasing hormone

DHEA

Dehydroepiandrosterone

EDSS

Expanded Disability Status Scale

GPx

Glutathione peroxidase

HARS

Hamilton anxiety rating scale

HDRS

Hamilton depression rating scale

HPA

Hypothalamic–pituitary–adrenal axis

IGF

Insulin-like growth factor

IL

Interleukin

MRI

Magnetic resonance image

MS

Multiple sclerosis

POMC

Pro-opiomelanocortin

PPMS

Primary-progressive multiple sclerosis

PRMS

Progressive-relapsing multiple sclerosis

RNS

Reactive nitrogen species

ROS

Reactive oxygen species

RRMS

Relapsing-remitting multiple sclerosis

SOD

Superoxide dismutase

SPMS

Secondary-progressive multiple sclerosis

TAS

Total antioxidative status

TNF

Tumor necrosis factor

UA

Uric acid

WBCT

Whole-body cryotherapy

Notes

Acknowledgments

I would like to thank all staff of the Department of General Biochemistry at the University of Lodz in Poland, especially Professor Barbara Wachowicz, for support and very useful comments.

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Authors and Affiliations

  1. 1.Department of Physical MedicineMedical University of LodzLodzPoland
  2. 2.Neurorehabilitation Ward, III General Hospital in LodzLodzPoland

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