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Mitochondrial Dysfunction in Psychiatric Disorders

Chapter
Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)

Abstract

Psychiatric disorders represent a large class of medical disorders with unclear etiologies and limited effective treatments. Mitochondrial dysfunction is particularly interesting as it can manifest a wide variety of symptoms including abnormalities in central nervous system functioning with focal neurological, cognitive, behavioral, and psychiatric symptoms. Evidence has started to accumulate that mitochondrial dysfunction plays a role in schizophrenia, major depression, bipolar disorder, personality/mood disorders, Alzheimer’s disease, and autism spectrum disorders. The prevalence of mitochondrial dysfunction in these disorders is not clear. Studies reporting laboratory testing for the identification of mitochondrial dysfunction and treatments in these disorders are generally lacking. Notably, the identification of mitochondrial dysfunction in psychiatric conditions could lead to the development of better medications and other treatments for these conditions that target specific metabolic abnormalities. Although the evidence for mitochondrial dysfunction in psychiatric disorders is increasing, additional studies are warranted.

Keywords

Autism Spectrum Disorder Autism Spectrum Disorder Psychiatric Disorder Bipolar Disorder Mitochondrial Dysfunction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

ADP

Adenosine diphosphate

ASD

Autism spectrum disorder

ATP

Adenosine triphosphate

CNS

Central nervous system

ETC

Electron transport chain

FADH2

Flavin adenine dinucleotide

GSH

Glutathione

MD

Mitochondrial disorder

MELAS

Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes

mtDNA

Mitochondrial DNA

NAC

N-acetylcysteine

NADH

Nicotinamide adenine dinucleotide

nDNA

Nuclear DNA

OCD

Obsessive-compulsive disorder

POLG1

Polymerase gamma-1

ROS

Reactive oxygen species

TCA

Tricarboxylic acid

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Rossignol Medical CenterIrvineUSA
  2. 2.Department of PediatricsArkansas Children’s Hospital Research Institute, University of Arkansas for Medical SciencesLittle RockUSA

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