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Cytogenetics of Melanoma and Nonmelanoma Skin Cancer

  • Melanie A. Carless
  • Lyn R. GriffithsEmail author
Chapter

Abstract

Cytogenetic analysis of melanoma and nonmelanoma skin cancers has revealed recurrent aberrations, the frequency of which is reflective of malignant potential. Highly aberrant kaiyotypes are seen in melanoma, squamous cell carcinoma, actinic keratosis, Merkel cell carcinoma and cutaneous lymphomas with more stable karyotypes seen in basai cell carcinoma, keratoacanthoma, Bowen's disease and dermatofibrosarcoma protuberans. Some aberrations are common among a number of skin cancer types including rearrangements and numerical abnormalities of chromosome 1, -3p, +3q, partial or entire trisomy 6, trisomy 7, +8q, -9p, +9q, partial or entire loss of chromosome 10, -17p, +17q and partial or entire gain of chromosome 20. Combination of cytogenetic analysis with other molecular genetic techniques has enabled the identification of not only aberrant chromosomal regions, but also the genes that contribute to a malignant phenotype. This review provides a comprehensive summaiy of the pertinent cytogenetic aberrations associated with a variety of melanoma and nonmelanoma skin cancers.

Keywords

Skin Cancer Basal Cell Carcinoma Comparative Genomic Hybridization Merkel Cell Carcinoma Mycosis Fungoides 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media, LCC 2014

Authors and Affiliations

  1. 1.Department of GeneticsTexas Biomedical Research InstituteSan AntonioUSA
  2. 2.Genomics Research Centre, School of Health Science,Griffith University Gold CoastBundallAustralia

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