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Protection from Ultraviolet Damage and Photocarcinogenesis by Vitamin D Compounds

  • Clare Gordon-Thomson
  • Wannit Tongkao-on
  • Eric J. Song
  • Sally E. Carter
  • Katie M. Dixon
  • Rebecca S. MasonEmail author
Chapter

Abstract

Vitamin D is primarily produced by a photochemical reaction in skin, using the energy of ultraviolet B radiation. Ultraviolet radiation in sunlight is also responsible for several types of DNA damage, immunosuppression and photoaging. A number of adaptive responses are known to occur in skin to increasing UV exposure, including increased pigmentation, increased thickness of the cornified layer of skin and upregulation of DNA repair pathways. In addition to these known responses, there is now sufficient evidence to suggest that the local vitamin D system in skin, which includes local production of the active hormone, l,25dihydroxyvitamin D, together with metabolites of over-irradiation products, and vitamin D receptor(s), also provide an adaptive response to UV. The vitamin D system in skin reduces DNA damage, inflammation and photocarcinogenesis. Because vitamin D is made in skin, sun damage is less than it would be otherwise.

Keywords

Actinic Keratose Cyclobutane Pyrimidine Dimer Thymine Dimer Urocanic Acid Global Genome Repair 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media, LCC 2014

Authors and Affiliations

  • Clare Gordon-Thomson
    • 1
  • Wannit Tongkao-on
    • 1
  • Eric J. Song
    • 1
  • Sally E. Carter
    • 1
  • Katie M. Dixon
    • 1
  • Rebecca S. Mason
    • 1
    Email author
  1. 1.Departments of Physiology, Anatomy and Histology, and the Bosch Institute for Medical Research, School of Medical SciencesThe University of SydneySydneyAustralia

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