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Is a Cure for HIV Possible?

  • Gerhard Bauer
  • Joseph S. Anderson
Chapter
Part of the SpringerBriefs in Biochemistry and Molecular Biology book series (BRIEFSBIOCHEM)

Abstract

It may be very difficult to achieve a sterilizing cure for HIV; however, it may be entirely possible to achieve a functional cure for HIV if a large enough number of HIV-resistant hematopoietic stem cells is transplanted into an HIV-infected recipient, eventually creating an immune system that can control the virus. This has been demonstrated in one patient who received a bone marrow transplant from a donor with a naturally occurring CCR5 deletion. If stem cell gene therapy with autologous cells can be performed with the vast majority of the cells expressing anti-HIV activity, a similar outcome can be expected. In the future, stem cells may also be generated from pluripotent stem cells, particularly induced pluripotent stem cells, promising large numbers of tested, HIV-resistant autologous stem cells for patients with HIV.

Keywords

Acute Myeloid Leukemia Hematopoietic Stem Cell Pluripotent Stem Cell CCR5 Receptor Sooty Mangabey 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 81.
    Allers K et al (2011) Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation. Blood 117(10):2791–2799CrossRefPubMedGoogle Scholar
  2. 120.
    Hutter G et al (2009) Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med 360(7):692–698CrossRefPubMedGoogle Scholar

Copyright information

© Gerhard Bauer and Joseph S. Anderson 2014

Authors and Affiliations

  • Gerhard Bauer
    • 1
  • Joseph S. Anderson
    • 1
  1. 1.University of California DavisSacramentoUSA

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