Is a Cure for HIV Possible?
It may be very difficult to achieve a sterilizing cure for HIV; however, it may be entirely possible to achieve a functional cure for HIV if a large enough number of HIV-resistant hematopoietic stem cells is transplanted into an HIV-infected recipient, eventually creating an immune system that can control the virus. This has been demonstrated in one patient who received a bone marrow transplant from a donor with a naturally occurring CCR5 deletion. If stem cell gene therapy with autologous cells can be performed with the vast majority of the cells expressing anti-HIV activity, a similar outcome can be expected. In the future, stem cells may also be generated from pluripotent stem cells, particularly induced pluripotent stem cells, promising large numbers of tested, HIV-resistant autologous stem cells for patients with HIV.
KeywordsAcute Myeloid Leukemia Hematopoietic Stem Cell Pluripotent Stem Cell CCR5 Receptor Sooty Mangabey