Is a Cure for HIV Possible?

  • Gerhard Bauer
  • Joseph S. Anderson
Part of the SpringerBriefs in Biochemistry and Molecular Biology book series (BRIEFSBIOCHEM)


It may be very difficult to achieve a sterilizing cure for HIV; however, it may be entirely possible to achieve a functional cure for HIV if a large enough number of HIV-resistant hematopoietic stem cells is transplanted into an HIV-infected recipient, eventually creating an immune system that can control the virus. This has been demonstrated in one patient who received a bone marrow transplant from a donor with a naturally occurring CCR5 deletion. If stem cell gene therapy with autologous cells can be performed with the vast majority of the cells expressing anti-HIV activity, a similar outcome can be expected. In the future, stem cells may also be generated from pluripotent stem cells, particularly induced pluripotent stem cells, promising large numbers of tested, HIV-resistant autologous stem cells for patients with HIV.


Acute Myeloid Leukemia Hematopoietic Stem Cell Pluripotent Stem Cell CCR5 Receptor Sooty Mangabey 
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    Allers K et al (2011) Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation. Blood 117(10):2791–2799CrossRefPubMedGoogle Scholar
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    Hutter G et al (2009) Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med 360(7):692–698CrossRefPubMedGoogle Scholar

Copyright information

© Gerhard Bauer and Joseph S. Anderson 2014

Authors and Affiliations

  • Gerhard Bauer
    • 1
  • Joseph S. Anderson
    • 1
  1. 1.University of California DavisSacramentoUSA

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