Abstract
In the beginning of HIV research, there were no murine models for HIV, as HIV could not infect murine cells. During the last decade, immunodeficient mouse models were refined and could be applied for engraftment of human hematopoietic stem cells, generating a functional human immune system in these animals. Human immune cells generated in vivo could then be infected with HIV, and anti-HIV gene therapy applications could be tested in these mice. Nonhuman primates are also utilized for HIV research; however, the simian immunodeficiency virus (SIV) or a hybrid HIV–SIV needs to be applied for viral challenges.
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References
Anderson J et al (2007) Safety and efficacy of a lentiviral vector containing three anti-HIV genes–CCR5 ribozyme, tat-rev siRNA, and TAR decoy–in SCID-hu mouse-derived T cells. Mol Ther 15(6):1182–1188
Joseph A, Sango K, Goldstein H (2009) Novel mouse models for understanding HIV-1 pathogenesis. Methods Mol Biol 485:311–327
Brainard DM et al (2009) Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice. J Virol 83(14):7305–7321
Shultz LD, Ishikawa F, Greiner DL (2007) Humanized mice in translational biomedical research. Nat Rev Immunol 7(2):118–130
Walker JE et al (2012) Generation of an HIV-1-resistant immune system with CD34(+) hematopoietic stem cells transduced with a triple-combination anti-HIV lentiviral vector. J Virol 86(10):5719–5729
Stoddart CA et al (2007) Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals. PLoS One 2(7):e655
Bauer G et al (2008) In vivo biosafety model to assess the risk of adverse events from retroviral and lentiviral vectors. Mol Ther 16(7):1308–1315
Poropatich K, Sullivan DJ Jr (2011) Human immunodeficiency virus type 1 long-term non-progressors: the viral, genetic and immunological basis for disease non-progression. J Gen Virol 92(Pt 2):247–268
Meythaler M et al (2011) Early induction of polyfunctional simian immunodeficiency virus (SIV)-specific T lymphocytes and rapid disappearance of SIV from lymph nodes of sooty mangabeys during primary infection. J Immunol 186(9):5151–5161
Hartigan-O’Connor DJ et al (2012) SIV replication in the infected rhesus macaque is limited by the size of the preexisting TH17 cell compartment. Sci Transl Med 4(136):136ra69
Zhang J et al (2011) Retroviral restriction factors TRIM5alpha: therapeutic strategy to inhibit HIV-1 replication. Curr Med Chem 18(17):2649–2654
Barsov EV et al (2011) Transduction of SIV-specific TCR genes into rhesus macaque CD8+ T cells conveys the ability to suppress SIV replication. PLoS One 6(8):e23703
Rosenzweig M et al (1997) Intracellular immunization of rhesus CD34+ hematopoietic progenitor cells with a hairpin ribozyme protects T cells and macrophages from simian immunodeficiency virus infection. Blood 90(12):4822–4831
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© 2014 Gerhard Bauer and Joseph S. Anderson
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Bauer, G., Anderson, J.S. (2014). Animal Models Used in HIV Gene Therapy. In: Gene Therapy for HIV. SpringerBriefs in Biochemistry and Molecular Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0434-1_6
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DOI: https://doi.org/10.1007/978-1-4939-0434-1_6
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