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History of Gene Therapy

  • Gerhard Bauer
  • Joseph S. Anderson
Chapter
Part of the SpringerBriefs in Biochemistry and Molecular Biology book series (BRIEFSBIOCHEM)

Abstract

Gene therapy had its start in the 1970s, including the creation of a regulatory body for gene therapy, the Recombinant DNA Advisory Committee (RAC). The first retroviral-mediated gene therapy clinical trials started in 1990, and the first stem cell gene therapy clinical trial (ADA deficiency), also retrovirally mediated, was initiated in 1994. The first stem cell gene therapy clinical trial for pediatric HIV was conducted in 1997, followed by a stem cell gene therapy for HIV clinical trial in adults with lymphoma using complete marrow ablation in 1999. In October of 1999, the death of Jesse Gelsinger in a clinical trial applying adenoviral vector in vivo was reported. In 2002, leukemia induced by insertional mutagenesis of an integrated retroviral vector in children treated with stem cell gene therapy for X-linked SCID in France was reported.

Keywords

Gene Therapy Gauche Disease Gene Therapy Study Gene Therapy Protocol Gene Therapy Clinical Trial 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Gerhard Bauer and Joseph S. Anderson 2014

Authors and Affiliations

  • Gerhard Bauer
    • 1
  • Joseph S. Anderson
    • 1
  1. 1.University of California DavisSacramentoUSA

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