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MicroRNA, DNA Repair, and Cancer

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MicroRNA in Development and in the Progression of Cancer

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Abstract

Genomic instability is a hallmark of cancer cells and one of the underlying mechanisms is probably caused by the failure to repair DNA damages that have been passed on to the progeny cells. Cells have evolved many types of DNA repair mechanisms to counteract the DNA damages induced by exogenous insults, such as ionizing radiation, ultraviolet radiation, and chemical reagents, or endogenous stimuli-like reactive oxygen species (ROS). These repair mechanisms constitute an elaborate genome maintenance system to protect genomic integrity and therefore defend tumorigenesis. Most recently, microRNAs (miRNAs) have been reported to be a new class of regulators that modulate the DNA damage response pathways by targeting the protein components of response machinery. Here, we summarize and highlight the miRNAs that have been shown to regulate the different DNA repair pathways and discuss their roles in carcinogenesis and implications in cancer therapy.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, 90095, Los Angeles, CA, USA

    Hailiang Hu

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  1. Hailiang Hu
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Correspondence to Hailiang Hu .

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Editors and Affiliations

  1. National Cancer Institute Mouse Cancer Genetics Program, Frederick, Maryland, USA

    Shree Ram Singh

  2. UMDNJ-NJ Medical School, Newark, New Jersey, USA

    Pranela Rameshwar

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Hu, H. (2014). MicroRNA, DNA Repair, and Cancer. In: Singh, S., Rameshwar, P. (eds) MicroRNA in Development and in the Progression of Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-8065-6_3

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