Abstract
The derivation of stem cells in domestic animal species represents a great improvement in developmental biology and could provide a powerful tool for regenerative medicine and genetic engineering. Despite the enormous efforts and work dedicated to the establishment of stem cell lines from large animals, no conclusive results have been obtained so far, and validated lines have yet to be established.
Here we summarize the data presently available on functional key pluripotency-maintaining pathways and stemness-related marker molecules that can be used to reliably investigate pluripotency in domestic animals.
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Brevini, T.A.L., Gandolfi, F. (2013). Pluripotency in Domestic Animal Embryos. In: Pluripotency in Domestic Animal Cells. SpringerBriefs in Stem Cells. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-8053-3_2
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DOI: https://doi.org/10.1007/978-1-4899-8053-3_2
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