Chapter

Nanotechnology and Neuroscience: Nano-electronic, Photonic and Mechanical Neuronal Interfacing

pp 207-238

Date:

Active Pixel Sensor Multielectrode Array for High Spatiotemporal Resolution

  • L. BerdondiniAffiliated withNetS3 Laboratory, Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia Email author 
  • , A. BoscaAffiliated withNetS3 Laboratory, Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia
  • , T. NieusAffiliated withNetS3 Laboratory, Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia
  • , A. MaccioneAffiliated withNetS3 Laboratory, Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia

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Abstract

Among the different methodologies used for electrophysiological measures in the brain, electrodes have played an undisputed role in high-quality intracellular signal recordings from a few neurons and in chronic extracellular measures with electrode-array probes implanted in the brain. Electrode arrays providing multisite extracellular measures have become a key methodology in neuroscience for studying coding and transmission of information by neuronal ensembles [1] and for the development of Brain–Machine Interfaces (BMIs) and neural prosthetics [2–8]. This is mainly because electrode arrays combine the unique features of bidirectionality (i.e., recording and stimulation), long-term stability (up to years), and of a large signal bandwidth that enables recordings of action potentials from multiple neurons as well as low-frequency field potentials (LFPs).