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Oxidative Stress and Complications of the Diabetic Foot

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Studies in Diabetes

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Abstract

The leading factor contributing to amputation in diabetes is usually diabetic foot disease and ulceration. The optimal approach to the management of complications of the lower limb in diabetes lies in prevention through the implementation of screening programs aimed at the early detection of neuropathy, ischemia, deformity, and edema. However, even with aggressive screening, chronic ulceration of the lower limbs remains one of the most common and serious consequences of diabetes. Understanding the causes of diabetic foot ulceration is critical to supplement traditional management approaches. In diabetes, recent evidence suggests that skin structural and functional deficits may contribute to the risk of developing foot ulceration. In diabetes, oxidative and nitrosative stress are implicated in the development of wide-ranging complications including neuropathy, and evidence is accumulating that it may play an important role in the development of skin structural and perfusion deficits, foot ulceration, and impaired wound healing. Better understanding of the causes of these deficits may offer the opportunity to develop new therapeutic approaches which may ultimately reduce the risk of developing this common and disabling complication of diabetes.

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Authors and Affiliations

  1. Centre of Endocrinology Diabetes and Metabolism (CEDAM), School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, B15 2TT, UK

    Martin J. Stevens

  2. Department of Diabetes and Endocrinology, Heart of England NHS Foundation Trust, Birmingham, UK

    Martin J. Stevens

  3. Department of Diabetes and Endocrinology, Heart of England National Health Service Foundation Trust, Birmingham, UK

    Jayadave Shakher

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  1. Martin J. Stevens
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  2. Jayadave Shakher
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Correspondence to Martin J. Stevens .

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Editors and Affiliations

  1. Louisiana State University Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA

    Irina Obrosova

  2. Centre for Endocrinology and Metabolism, University of Brimingham, School of Clinical and Experimental Medicine, Birmingham, United Kingdom

    Martin J. Stevens

  3. Veterans Affairs Medical Center, University of Iowa, Iowa City, Iowa, USA

    Mark A. Yorek

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Stevens, M.J., Shakher, J. (2014). Oxidative Stress and Complications of the Diabetic Foot. In: Obrosova, I., Stevens, M., Yorek, M. (eds) Studies in Diabetes. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4899-8035-9_7

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