A Microvascular Model in Skeletal Muscle Fascia

  • Frank G. Jacobitz
  • Niki L. Yamamura
  • Adam M. Jones
  • Geert W. Schmid-SchönbeinEmail author


This study considers the microcirculation in skelet al muscle fascia. Simulations are performed using a comprehensive approach to the problem with realistic reconstruction of the microvasculature, blood rheology and vessel wall properties, and Stokes flow in the microvessels. The simulation results provide detailed network displays of basic hemodynamic parameters. For example, an approximately normal distribution was found for the hematocrit. High hematocrit values are observed in areas with low blood perfusion, e.g., in the peripheral regions of the network. A range of velocity values was found in the capillary vessels of the network, in contrast to experimental observations which suggest a relative narrow distribution of capillary velocities. This finding points to the need of an improved treatment of mechanisms for the control of vessel diameter. A local mechanism based on the shear stress is proposed for future studies of the microcirculation.


Microcirculation Stokes flow Fascia Shear stress Local regulation 


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Copyright information

© Springer Science+Business Media, LLC 2016

Authors and Affiliations

  • Frank G. Jacobitz
    • 1
  • Niki L. Yamamura
    • 1
  • Adam M. Jones
    • 1
  • Geert W. Schmid-Schönbein
    • 2
    Email author
  1. 1.Mechanical Engineering ProgramUniversity of San DiegoSan DiegoUSA
  2. 2.Department of BioengineeringUniversity of California, San DiegoLa JollaUSA

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