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Structure-Based Mechanics of Tissues and Organs pp 403–415Cite as

A Microvascular Model in Skeletal Muscle Fascia

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Abstract

This study considers the microcirculation in skelet al muscle fascia. Simulations are performed using a comprehensive approach to the problem with realistic reconstruction of the microvasculature, blood rheology and vessel wall properties, and Stokes flow in the microvessels. The simulation results provide detailed network displays of basic hemodynamic parameters. For example, an approximately normal distribution was found for the hematocrit. High hematocrit values are observed in areas with low blood perfusion, e.g., in the peripheral regions of the network. A range of velocity values was found in the capillary vessels of the network, in contrast to experimental observations which suggest a relative narrow distribution of capillary velocities. This finding points to the need of an improved treatment of mechanisms for the control of vessel diameter. A local mechanism based on the shear stress is proposed for future studies of the microcirculation.

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Authors and Affiliations

  1. Mechanical Engineering Program, University of San Diego, San Diego, CA, USA

    Frank G. Jacobitz, Niki L. Yamamura & Adam M. Jones

  2. Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA

    Geert W. Schmid-Schönbein

Authors
  1. Frank G. Jacobitz
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  2. Niki L. Yamamura
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  3. Adam M. Jones
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  4. Geert W. Schmid-Schönbein
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Corresponding author

Correspondence to Geert W. Schmid-Schönbein .

Editor information

Editors and Affiliations

  1. California Medical Innovations Institute , INDIANAPOLIS, Indiana, USA

    Ghassan S. Kassab

  2. Institute for Computational Engineering, The University of Texas at Austin Institute for Computational Engineering, PITTSBURGH, Pennsylvania, USA

    Michael S. Sacks

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Jacobitz, F.G., Yamamura, N.L., Jones, A.M., Schmid-Schönbein, G.W. (2016). A Microvascular Model in Skeletal Muscle Fascia. In: Kassab, G., Sacks, M. (eds) Structure-Based Mechanics of Tissues and Organs. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7630-7_20

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