Potential Mechanism of PTA: Alterations in Joint Loading


The complex interaction between biomechanics and biology in the etiology and progression of arthritis remains unknown. The challenge becomes one of understanding joint mechanics in both normal and traumatized joints. This requires consideration of how loads are transferred across the joint, how they are distributed among the joint tissues, and how injury affects joint stability. Lessons learned from tribology of man-made joints underscore the importance of the interaction between joint force and stability. Animal models used to induce arthritic changes, often by creating joint instability, are hampered by poor control and inadequate measurement of the mechanical environment. However, considerable progress is underway, supported by increases in computational tools and computing power, the availability of mouse models that can incorporate specific genetic alterations, and more robust imaging techniques for longitudinally modeling the resulting alterations in joint tissues.


Joint stability Biomechanics Joint load Joint kinematics Load transfer Joint contact Wear 


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of BiomechanicsHospital for Special SurgeryNew YorkUSA

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