Survey of Animal Models in Post-Traumatic Arthritis: Choosing the Right Model to Answer the Right Question

  • Bridgette D. Furman
  • Kelly A. Kimmerling
  • Chia-Lung Wu
  • Dianne Little
  • Farshid Guilak
  • Steven A. Olson


The selection of a model to study post-traumatic arthritis is a challenging and potentially confusing decision. This chapter was added specifically to address questions investigators may have when considering moving their work into an animal model. It is not possible to cover every possible species of animal that could be used. Therefore, this chapter provides a comprehensive review of the various aspects of arthritis after joint injury that can be studied in three commonly used species. This work provides an overview of what assays, information, and data can be available to the investigators. It is important that investigators are certain they will be able to collect data to address their research question before the investigation begins.


Experimental model Murine Mice Canine Dog Rabbit Post-traumatic arthritis 



Supported in part by the Arthritis Foundation, the Department of Defense, the Collaborative Research Center, AO Foundation, Davos Switzerland, and NIH grants AR48182, AR48852, AG15768, AR50245, and AG46927.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Bridgette D. Furman
    • 1
  • Kelly A. Kimmerling
    • 2
  • Chia-Lung Wu
    • 3
  • Dianne Little
    • 4
  • Farshid Guilak
    • 5
  • Steven A. Olson
    • 5
  1. 1.Department of Orthopedic SurgeryDuke University Medical CenterDurhamUSA
  2. 2.Departments of Orthopedic Surgery and Biomedical EngineeringDuke University Medical CenterDurhamUSA
  3. 3.Department of Orthopedic SurgeryDuke University Medical CenterDurhamUSA
  4. 4.Department of Orthopedic SurgeryDuke University Medical CenterDurhamUSA
  5. 5.Department of Orthopedic SurgeryDuke University Medical CenterDurhamUSA

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