High-Resolution fMRI

Part of the Biological Magnetic Resonance book series (BIMR, volume 30)


High-resolution functional magnetic resonance imaging (fMRI) is motivated by the desire to understand how the brain is organized and functions at the most fundamental levels. To date, there have been several submillimeter applications of fMRI which have been successful in mapping out columnar organizations as well as measuring depth-dependent information, reflective of neuronal processing and interactions across cortical layers. The usefulness and efficiency of high-resolution fMRI depends on a variety of different factors. Among these factors is the ability to acquire higher-resolution images over a sufficiently large field of view (FOV) in a reasonable acquisition time. Longer acquisition times result in an increase in the voxel point spread function and a decrease in the efficiency of the fMRI paradigm. Smaller FOVs limit the ability to obtain information and functional maps simultaneously across several cortical areas. Further, any motion in the data is difficult to correct. The sensitivity and efficiency of the high-resolution images can be improved by using localized coil arrays which provide higher signal-to-noise ratio (SNR) and the ability to accelerate the imaging. Alternative pulse sequences which affect SNR, efficiency, and functional contrast, are also integral parts of optimizing high-resolution acquisitions. Also, higher magnetic fields are paramount to obtaining sufficient sensitivity and specificity in the functional images. Ultimately, however, one of the single biggest factors in the successful acquisition of high-resolution fMRI is the ability and cooperation of human subjects to remain still and attentive over extended periods of time.


Anisotropy Manifold Foam Mold Radar 


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Copyright information

© Springer New York 2015

Authors and Affiliations

  1. 1.Center for MR ResearchUniversity of MinnesotaMinneapolisUSA
  2. 2.Montreal Neurological Institute and HospitalMcGill UniversityMontrealCanada

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