Metastatic Tumors

  • Yener S. Erozan
  • Ibrahim Ramzy
Part of the Essentials in Cytopathology book series (EICP, volume 15)


In this chapter, in addition to the cytopathologic features, a brief discussion of clinical aspects and the approach to diagnosis of the primary site and type of tumor are given.

Metastatic carcinomas are presented in categories of type and pattern. In each category, differential diagnosis is discussed comparing the cytopathologic features and immunoprofile of specific tumors. The second edition has been updated with the latest immunologic markers that help in the differential diagnosis.


Renal Cell Carcinoma Signet Ring Cell Endometrial Stromal Sarcoma Clear Cell Sarcoma Psammoma Body 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Suggested Reading

  1. Chhieng DC, Cangiarella JF, Zakowski MF, et al. Use of thyroid transcription factor 1, PE-10, and cytokeratins 7 and 20 in discriminating between primary lung carcinomas and metastatic lesions in fine-needle aspiration biopsy specimens. Cancer. 2001;93:330–6.PubMedCrossRefGoogle Scholar
  2. Crosby JH, Hoeg K, Hager B. Transthoracic fine needle aspiration of primary and metastatic sarcomas. Diagn Cytopathol. 1985;1:221–7.PubMedCrossRefGoogle Scholar
  3. Dabbs DJ. Diagnostic immunohistochemistry. ed 4. Philadelphia, PA: Elsevier-Saunders; 2014.Google Scholar
  4. Gruver AM, Amin MB, Luthringer DJ, et al. Selective immunohistochemical markers to distinguish between metastatic high-grade urothelial carcinoma and primary poorly differentiated invasive squamous cell carcinoma of the lung. Arch Pathol Lab Med. 2012;136:1339–46.PubMedCrossRefGoogle Scholar
  5. Horn A, Chakraborty S, Dey P, et al. Immunocytochemistry for MUC4 and MUC16 is a useful adjunct in the diagnosis of pancreatic adenocarcinoma on fine-needle aspiration cytology. Arch Pathol Lab Med. 2013;137:546–51.PubMedCentralPubMedCrossRefGoogle Scholar
  6. Rother J, Jones D. Molecular markers of tumor progression in melanoma. Curr Genomics. 2009;10:231–9.PubMedCentralPubMedCrossRefGoogle Scholar
  7. Zeppa P, Cozzolino I, Russo M, et al. Pulmonary langerhans cell histiocytosis (Histiocytosis X) on bronchoalveolar lavage: A report of 2 cases. Acta Cytol. 2007;51:480–6.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Yener S. Erozan
    • 1
  • Ibrahim Ramzy
    • 2
    • 3
  1. 1.Department of PathologyThe Johns Hopkins School of MedicineBaltimoreUSA
  2. 2.Departments of Pathology - Laboratory Medicine & of Obstetrics-GynecologyUniversity of CaliforniaIrvineUSA
  3. 3.Department of PathologyBaylor College of MedicineHoustonUSA

Personalised recommendations