Peripheral T-cell lymphomas

  • Harald Stein
  • Dieter Dienemann
  • Friederike Dallenbach
  • Michael Kruschwitz


The development of T cells from stem (progenitor) cells to effector cells results from a two-wave process of proliferation and differentiation. The cells of the first differentiation wave are the precursor T cells, and those of the second differentiation wave are peripheral T cells. In the first differentiation wave, resting/circulating naive antigen-reactive T lymphocytes are produced which differ from each other in their antigen receptor-specificity. In the second differentiation wave, those T lymphocytes multiply whose antigen receptors have found the corresponding antigen. Thus three major forms of differentiation can be distinguished in the peripheral T cells: (1) resting/circulating naive antigen-reactive T cells, (2) activated T cells, and (3) effector T cells and memory T cells. In addition, there are at least three major organ-restricted sublines of peripheral T cells, i.e., nodal T cells, mucosa-associated T cells, and skin-associated T cells. Thanks to the availability of markers for most of the above-mentioned T-cell sublines and differentiation forms, all these cellular forms can be associated with certain lymphoma types, i.e., lymphomas of T-cell type can be divided into categories of precursor T-cell lymphomas and peripheral T-cell lymphomas. The peripheral T-cell lymphomas can be subdivided into those derived from lymph nodal, mucosal, and cutaneous T cells. The gut mucosal T-cell lymphomas are associated with enteropathy. The lymph node, mucosal, and cutaneous T-cell lymphomas can be further subdivided into those in which all tumor cells are similar to recirculating resting (nonactivated) T cells, those in which some of the tumor cells resemble activated T cells, and those in which all tumor cells resemble activated T cells. The second group includes pleomorphic T-cell lymphoma, Lennert’s lymphoma, and angioimmunoblastic T-cell lymphoma, and the third group includes Ki-1+ (CD30+) anaplastic large-cell (ALC) lymphomas of T-cell type. The apparently constant association of Ki-1+ T-ALC lymphoma with the breakpoint 5q35 underlines the justification of its classification as a separate entity.


Celiac Disease Antigen Receptor Anaplastic Large Cell Lymphoma Hairy Cell Leukemia Differentiation Wave 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 1991

Authors and Affiliations

  • Harald Stein
    • 1
  • Dieter Dienemann
    • 1
  • Friederike Dallenbach
    • 1
  • Michael Kruschwitz
    • 1
  1. 1.Institute of Pathology, Steglitz Medical CenterFree University of BerlinBerlinGermany

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