The chemistry of biological macromolecules and their degradation

  • R. T. Dean
Part of the Outline Studies in Biology book series (OSB)


The nature of each of the main groups of cellular macromolecules is outlined here, and followed in each case by a description of the main degradative enzymes likely to act on the substrates, and their mode of action. The most important degradative reaction is hydrolysis; to illustrate the immense potential of cellular hydrolytic enzymes, the current classification of these enzymes, together with their enzyme group numbers (E.C.) is shown in Table 3.1. Since each group comprises several enzymes, the enzyme armoury is impressive.


Lysosomal Enzyme Lysosomal Storage Disease Compound Lipid Simple Lipid Peptide Hydrolase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Barman, T. E. (1969), The Enzyme Handbook — Vols. 1 and 2, Springer, Vienna.CrossRefGoogle Scholar
  2. Summarized information on all known enzymes.Google Scholar
  3. Methods in Enzymology.Google Scholar
  4. Recent volumes cover in more detail most of the hydrolases of interest.Google Scholar
  5. Barret, A. J. (1977) (Edit.)Proteinases in Mammalian Cells and Tissues, North Holland, Amsterdam.Google Scholar
  6. An excellent comprehensive treatise.Google Scholar
  7. Barrett, A. J. and Heath, M. F. (1977), in Lysosomes, a laboratory handbook, 2nd edition. (Ed.) J. T. Dingle, pp. 19-145, North Holland, Amsterdam.Google Scholar

Copyright information

© R. T. Dean 1978

Authors and Affiliations

  • R. T. Dean
    • 1
  1. 1.Clinical Research CentreHarrowEngland

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