Metabolites, enzymes, and metabolite analogues

  • Adrien Albert


The smallest change in the chemical constitution of a selectively toxic agent often makes an enormous change in its biological activity, and many examples of this have been given in Chapter 7. The present chapter deals in greater detail with one of these cases of high specificity, namely that arising from a close resemblance between a normal substrate of an enzyme and an agent which inhibits it. Alternatively, the resemblance may be between the agent and a coenzyme. The products of the substrates can be referred to collectively as metabolites.


Folic Acid Malonic Acid Sequential Blocking Selective Toxicity Normal Substrate 
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Copyright information

© Adrien Albert 1973

Authors and Affiliations

  • Adrien Albert
    • 1
  1. 1.Australian Academy of Science, Department of Medical Chemistry in the John Curtin School of Medical ResearchAustralian National UniversityCanberraAustralia

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