The precise mechanism whereby methyldopa lowers blood pressure is not completely known, yet its antihypertensive effect is probably due to metabolism to alpha-methylnorepinephrine, which then lowers arterial pressure by stimulation of the central inhibitory alphaadrenergic receptors. False neurotransmission and/or reduction of plasma renin activity may also contribute to the action.
Keywords
- Arterial Pressure
- Orthostatic Hypotension
- Plasma Renin Activity
- Antihypertensive Effect
- Fixed Combination
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.