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TOP 200 pp 10–11Cite as

Aldomet® (Merck Sharp & Dohme)

Methyldopa

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Abstract

The precise mechanism whereby methyldopa lowers blood pressure is not completely known, yet its antihypertensive effect is probably due to metabolism to alpha-methylnorepinephrine, which then lowers arterial pressure by stimulation of the central inhibitory alphaadrenergic receptors. False neurotransmission and/or reduction of plasma renin activity may also contribute to the action.

Keywords

  • Arterial Pressure
  • Orthostatic Hypotension
  • Plasma Renin Activity
  • Antihypertensive Effect
  • Fixed Combination

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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  • DOI: 10.1007/978-1-4899-6746-6_6
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© 1982 Springer-Verlag Berlin Heidelberg

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Tallarida, R.J. (1982). Aldomet® (Merck Sharp & Dohme). In: TOP 200. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-6746-6_6

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  • DOI: https://doi.org/10.1007/978-1-4899-6746-6_6

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4899-6748-0

  • Online ISBN: 978-1-4899-6746-6

  • eBook Packages: Springer Book Archive