TOP 200 pp 30-31 | Cite as

Atarax® (Roerig)

Hydroxyzine HCl
  • Ronald J. Tallarida


Atarax is broadly classified as a tranquilizer. It is not chemically related to the phenothiazines, reserpine, or meprobamate. Hydroxyzine has been shown clinically to be a true rapid-acting ataraxic; it induces calming effects in anxious, tense psychoneurotic adults and also in hyperkinetic children without apparent impairment of mental alertness. It is not a cortical depressant, but its action may be due to suppression of its activity in certain key regions in the subcortical area of the central nervous system. Experimentally, hydroxyzine has been shown to have antispasmodic properties apparently mediated through interference with the mechanism that responds to spasmogenic agents such as serotonin, acetylcholine, and histamine. It also has antihistaminic effects and a possible antiemetic effect.


Serotonin Histamine Acetylcholine Urticaria Barbiturate 


  1. Baraf, CS: Curr Ther Res 19:32, 1976.PubMedGoogle Scholar
  2. Barranco, SF, Bridger, W: Curr Ther Res 22:217, 1977.Google Scholar
  3. Dilts, SL, et al: Am J Psychiat 134:92, 1977.PubMedGoogle Scholar
  4. Rhoades, RB, et al: J Allergy Clin Immunol 55:180, 1975.PubMedCrossRefGoogle Scholar
  5. Tobias, M, et al: J Dent Child 42:453, 1975.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • Ronald J. Tallarida
    • 1
  1. 1.Temple University School of MedicinePhiladelphiaUSA

Personalised recommendations