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Elongation Factor 3 — A Unique Fungal Protein

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New Approaches for Antifungal Drugs

Abstract

This chapter describes the structural features and the function of a novel fungal protein, elongation factor 3 (EF-3), which appears to be present only in the fungal family. The translational machinery of yeast is nonfunctional without this protein. A physical analog of EF-3 is absent in higher eukaryotes. Extensive knowledge of the structure and function of this unique yeast protein and comparative structural analyses of EF-3 with other eukaryotic translational factors is expected to provide a deeper understanding of the precise role of EF-3 in translation. The information in turn is expected to allow us to identify an inhibitory compound to interfere with the biological function of this unique fungal protein. Inhibitors of EF-3 function could potentially be exploited toward the development of a much needed antifungal agent. The increased number of immunosuppressed patients from the use of high dose chemotherapy, immunosuppressive drugs to support organ transplant, and increased incidence of acquired immunodeficiency syndrome (AIDS) has led to an increase in the number of systemic fungal infections by primary pathogens and opportunistic fungi (Sang et al., 1979). There is an ever-increasing demand to develop a more potent fungicidal agent with less toxic side effects to combat opportunistic infections in cancer and in immunocompromised diseases, such as AIDS. EF-3 may be such a unique target.

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Authors
  1. Kalpana Chakraburtty
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Editors and Affiliations

  1. Department of Microbial Molecular Biology, Bristol Myers Squibb Pharmaceutical Research Institute, 08543, Princeton, New Jersey, USA

    Prabhavathi B. Fernandes

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Chakraburtty, K. (1992). Elongation Factor 3 — A Unique Fungal Protein. In: Fernandes, P.B. (eds) New Approaches for Antifungal Drugs. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4899-6729-9_7

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  • DOI: https://doi.org/10.1007/978-1-4899-6729-9_7

  • Publisher Name: Birkhäuser, Boston, MA

  • Print ISBN: 978-1-4899-6731-2

  • Online ISBN: 978-1-4899-6729-9

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