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Inactivation of Herpes Simplex Virus Ribonucleotide Reductase by Subunit Association Inhibitors: A Potential Antiviral Strategy

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The Search for Antiviral Drugs

Abstract

The herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) represent two members of a group of at least seven human herpesviruses that includes varicella zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), and the more recently identified human herpesviruses 6 and 7 (HHV-6 and HHV-7). Infections caused by HSV are widespread in the human population and serological surveys have indicated that at least 9 out of 10 individuals in the United States have antibodies against these viruses (Fields, 1990). HSV-1 causes oral-labial, facial, and ocular infections, as well as more severe diseases such as encephalitis, whereas HSV-2 is more generally associated with genital herpes infections.

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Authors
  1. Michel Liuzzi
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  2. Robert Déziel
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Editors and Affiliations

  1. Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, CT, 06877-0368, USA

    Julian Adams  & Vincent J. Merluzzi  & 

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© 1993 Springer Science+Business Media New York

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Liuzzi, M., Déziel, R. (1993). Inactivation of Herpes Simplex Virus Ribonucleotide Reductase by Subunit Association Inhibitors: A Potential Antiviral Strategy. In: Adams, J., Merluzzi, V.J. (eds) The Search for Antiviral Drugs. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4899-6718-3_10

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  • DOI: https://doi.org/10.1007/978-1-4899-6718-3_10

  • Publisher Name: Birkhäuser, Boston, MA

  • Print ISBN: 978-1-4899-6720-6

  • Online ISBN: 978-1-4899-6718-3

  • eBook Packages: Springer Book Archive

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