Cingulothalamic and Prefrontal Control of Autonomic Function

  • Shirley L. Buchanan
  • Donald A. Powell


Well before the turn of the century, it was demonstrated that electrical stimulation of the cerebral cortex could elicit changes in autonomic systems (Eulenburg and Landois, 1876; Spencer, 1894). In the intervening years, many studies have suggested that dorsal anterior cingulate (area 24) and medial prefrontal cortices participate in such autonomic adjustments. This review begins with the background evidence that these areas mediate autonomic responses, the pathways that underlie such responses, and methodologies by which their role in learning may be studied. In subsequent sections, the contributions of cingulate and prefrontal cortices, and their related thalamic nuclei, to specific autonomic responses in the rabbit are reported as are their role in learned autonomic responses.


Conditioned Stimulus Classical Conditioning Nictitate Membrane Orient Reflex Unconditioned Stim 
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  1. Albiniak BA, Powell DA (1980): Peripheral autonomic mechanisms and Pavlovian conditioning in the rabbit (Oryctolagus cuniculus). J Comp Physiol Psychol 94:1101–1113Google Scholar
  2. Anand BK, Dua S (1956): Circulatory and respiratory changes induced by electrical stimulation of limbic system (visceral brain). J Neurophysiol 19:393–400Google Scholar
  3. Bailey P, Sweet WH (1940): Effects on respiration, blood pressure and gastric motility of stimulation of orbital surface of frontal lobe. J Neurophysiol 3:276–281Google Scholar
  4. Bard P, Mountcastle VB (1948): Some forebrain mechanisms involved in expression of rage with special reference to suppression of angry behavior. Res Publ—Assoc Res Nerv Ment Dis 27:362–404Google Scholar
  5. Beckstead RM (1979): An autoradiographic examination of corticocortical and subcortical projections of the mediodorsal-projection (prefrontal) cortex in the rat. J Comp Neurol 184:43–62Google Scholar
  6. Benjamin RM, Jackson JC, Golden GT (1978): Cortical projections of the thalamic mediodorsal nucleus in the rabbit. Brain Res 141:251–265Google Scholar
  7. Black AH (1972): The operant conditioning of central nervous system electrical activity. In: The Psychology of Learning and Motivation, Bower GH, ed. New York: Academic Press, Vol 6, pp 47–95Google Scholar
  8. Black AH, DeToledo L (1972): The relationship among classically conditioned responses: Heart rate and skeletal behavior. In: Classical Conditioning II: Current Theory and Research, Black AH, Prokasy WF, eds. New York: Appleton-Century-Crofts, pp 290–311Google Scholar
  9. Blass EM (1969): Thermoregulatory adjustments in rats after removal of the frontal poles of the brain. J Comp Physiol Psychol 69:83–90Google Scholar
  10. Brady JV (1967): Emotion and the sensitivity of psychoendocrine systems. In: Neurophysiology and Emotions, Glass DC, ed. New York: Rockefeller University Press, pp 70–95Google Scholar
  11. Brown DR, Randall DC, Raisch RM (1990): A temporally detailed reanalysis of the conditional heart rate response in dog. Physiol Behav 48:333–337Google Scholar
  12. Brown R, Kulik J (1977): Flashbulb memories. Cognition 5:73–99Google Scholar
  13. Bruner A (1969): Reinforcement strength in classical conditioning of leg flexion, freezing and heart rate in cats. Conditional Reflex 4:24–31Google Scholar
  14. Buchanan SL (1988): Mediodorsal thalamic lesions impair differential Pavlovian heart rate conditioning. Exp Brain Res 73:320–328Google Scholar
  15. Buchanan SL (1991): Differential and reversal Pavlovian conditioning in rabbits with medio-dorsal thalamic lesions: Assessment of heart rate and eyeblink responses. Exp Brain Res 86:174–181Google Scholar
  16. Buchanan SL, Powell DA (1982a): Cingulate cortex: Its role in Pavlovian conditioning. J Comp Physiol Psychol 96:755–774Google Scholar
  17. Buchanan SL, Powell DA (1982b): Cingulate damage attenuates conditioned bradycardia. Neurosci Lett 29:261–268Google Scholar
  18. Buchanan SL, Powell DA (1986): Electrical stimulation of anteromedial and mediodorsal thalamus elicits differential cardiovascular response patterns from conscious rabbits. Physiol Psychol 14:439–452Google Scholar
  19. Buchanan SL, Powell DA (1989): Parasagittal thalamic knife cuts and cardiac changes. Behav Brain Res 32:241–253Google Scholar
  20. Buchanan SL, Powell DA, Thompson RH (1989): Prefrontal projections to the medial nuclei of the dorsal thalamus in the rabbit. Neurosci Lett 106:55–59Google Scholar
  21. Buchanan SL, Thompson RH (1990): Mediodorsal thalamic lesions and Pavlovian conditioning of heart rate and eyeblink responses in the rabbit. Behav Neurosci 104:912–918Google Scholar
  22. Buchanan SL, Valentine JD, Powell DA (1985): Autonomic responses are elicited from medial but not lateral frontal cortex in rabbits. Behav Brain Res 18:51–62Google Scholar
  23. Burns SM, Wyss JM (1985): The involvement of the anterior cingulate cortex in blood pressure control. Brain Res 340:71–77Google Scholar
  24. Bykov KM (1957): The Cerebral Cortex and the Internal Organs, Gantt WH, transi. New York: Chemical Publishing CoGoogle Scholar
  25. Cannon WB (1929): Bodily Changes in Pain, Hunger, Fear and Rage. New York: Appleton-CenturyGoogle Scholar
  26. Cassell M, Wright D (1986): Topography of projections from the medial prefrontal cortex to the amygdala in the rat. Brain Res Bull 17:321–333Google Scholar
  27. Cechetto DF, Saper CB (1987): Evidence for a viscerotopic sensory representation in the cortex and thalamus in the rat. J Comp Neurol 262:27–45Google Scholar
  28. Clugnet M, LeDoux JE (1990): Synaptic plasticity in fear conditioning circuits: Induction of LTP in the lateral nucleus of the amygdala by stimulation of the medial geniculate body. J Neurosci 10:2818–2824Google Scholar
  29. Clugnet M, LeDoux JE, Morrison SF (1990): Unit responses evoked in the amygdala and striatum by electrical stimulation of the medial geniculate body. J Neurosci 10:1055–1061Google Scholar
  30. Cohen DH, Macdonald RL (1976): Involvement of the avian hypothalamus in defensively conditioned heart rate change. J Comp Neurol 167:465–480Google Scholar
  31. Cohen DH, Obrist PA (1975): Interactions between behavior and the cardiovascular system. Circ Res 37:693–706Google Scholar
  32. Cohen DH, Randall DC (1984): Classical conditioning of cardiovascular responses. Annu Rev Physiol 46:187–197Google Scholar
  33. Darrow CW (1937): Neural mechanisms controlling the palmar galvanic skin reflex and palmar sweating. Arch Neurol Psychiatry 37:641–663Google Scholar
  34. Delacour J (1984): Two neuronal systems are involved in a classical conditioning in the rat. Neuroscience 13:705–715Google Scholar
  35. Delgado JMR (1960): Circulatory effects of cortical stimulation. Physiol Rev 40:146–178Google Scholar
  36. Delgado JMR, Livingston RB (1948): Some respiratory, vascular and thermal responses to stimulation of orbital surface of frontal lobe. J Neurophysiol 11:39–55Google Scholar
  37. DeToledo L, Black AH (1966): Heart rate: Changes during conditioned suppression in rats. Science 152:1404–1406Google Scholar
  38. Deutch AY, Roth RH (1990): The determinants of stress-induced activation of the prefrontal cortical dopamine system. Prog Brain Res 85:367–403Google Scholar
  39. De Wied D (1980): Behavioral actions of neurohypophysial peptides. In: Neuroactive Peptides, Burgen A, Kosterlitz HW, Iversen LL, eds. London: Royal Society, pp 183–194Google Scholar
  40. Disterhoft JF, Coulter DA, Alkon DL (1988): Conditioning-specific biophysical alterations in rabbit hippocampus. In: Cellular Mechanisms of Conditioning and Behavioral Plasticity, Woody CD, Alkon DL, McGaugh JL, eds. New York: Plenum, pp 89–104Google Scholar
  41. Disterhoft JF, Olds J (1972): Differential development of conditioned unit changes in thalamus and cortex of rat. J Neurophysiol 35:665–679Google Scholar
  42. Duncan PM (1972): Effect of septal area damage and base-line activity levels on conditioned heart-rate response in rats. J Comp Physiol Psychol 81:131–142Google Scholar
  43. Dykman RA (1967): On the nature of classical conditioning. In: Methods in Psychophysiol-ogy, Brown CC, ed. Baltimore, MD: Williams & Wilkins, pp 234–283Google Scholar
  44. Dykman RA, Mack RL, Ackerman PT (1965): The evolution of autonomic and motor components of the non-avoidance conditioned response in the dog. Psychophysiology 1:209–230Google Scholar
  45. Elliot R (1974): The motivational significance of heart rate. In: Cardiovascular Psychophysiology: Current Issues in Response, Mechanisms, Biofeedback and Methodology, Obrist PA, Black AH, Brener J, Dicara LV, eds. Chicago: Aldine, pp 505–537Google Scholar
  46. Eulenburg A, Landois L (1876): Vasomotor effects from cortex. C R Hebd Seances Acad Sci 82:564Google Scholar
  47. Fehr FS, Stern JA (1970): Peripheral physiological variables and emotion: The James-Lange theory revisited. Psychol Bull 74:411–424Google Scholar
  48. Ferron A, Thierry AM, Le Douarin C, Glowinski J (1984): Inhibitory influence of the mesocor-tical dopaminergic system on spontaneous activity or excitatory responses induced from the thalamic mediodorsal nucleus in the rat medial prefrontal cortex. Brain Res 302:257–265Google Scholar
  49. Fitzgerald RD (1976): Involvement of vagal activity in the unconditioned heart-rate response of restrained rats. Physiol Behav 17:785–788Google Scholar
  50. Fitzgerald RD, Martin GK, O’Brien JH (1973): Influence of vagal activity on classically conditioned heart rate in rats. J Comp Physiol Psychol 83:485–491Google Scholar
  51. Fitzgerald RD, Teyler TJ (1970): Trace and delayed heart-rate conditioning in rats as a function of US intensity. J Comp Physiol Psychol 70:242–253Google Scholar
  52. Francis J, Hernandez LL, Powell DA (1981): Lateral hypothalamic lesions: Effects on Pav-lovian conditioning of eyeblink and heart rate responses in the rabbit. Brain Res Bull 6:155–163Google Scholar
  53. Frysztak RJ, Neafsey EJ (1987): Effects of rat medial frontal cortex lesions on conditioned emotional responses. Soc Neurosci Abstr 13:1551Google Scholar
  54. Fuster JM (1989): The Prefrontal Cortex: Anatomy, Physiology and Neuropsychology of the Frontal Lobe, 2nd ed. New York: Raven PressGoogle Scholar
  55. Gabriel M (1990): Functions of anterior and posterior cingulate cortex during avoidance learning in rabbits. Prog Brain Res 85:467–483Google Scholar
  56. Gabriel M, Sparenborg S, Kubota Y (1989): Anterior and medial thalamic lesions, discriminative avoidance learning, and cingulate cortical neuronal activity in rabbits. Exp Brain Res 76:441–457Google Scholar
  57. Gantt WH (1960): Cardiovascular component of the conditional reflex to pain, food, and other stimuli. Physiol Rev 40:266–291Google Scholar
  58. Gibbs CM, Powell DA (1988): Neuronal correlates of classically conditioned bradycardia in the rabbit: Studies of the medial prefrontal cortex. Brain Res 442:86–96Google Scholar
  59. Gibbs CM, Powell DA (1991): Single-unit activity in the dorsomedial prefrontal cortex during the expression of discriminative bradycardia in rabbits. Behav Brain Res 43:79–92Google Scholar
  60. Gibbs CM, Prescott LB, Powell DA (1992): A comparison of multiple-unit activity in the medial prefrontal and agranular insular cortices during Pavlovian heart rate conditioning in rabbits. Exp Brain Res, 89:599–610Google Scholar
  61. Ginn SR, Valentine JD, Powell DA (1983): Concomitant Pavlovian conditioning of heart rate and leg flexion responses in the rat. Pavlov J Biol Sci 18:154–160Google Scholar
  62. Goeders NE, Smith JE (1983): Cortical dopaminergic involvement in cocaine reinforcement. Science 221:773–775Google Scholar
  63. Gold PE, McGaugh JL (1977): Hormones and memory. In: Neuropeptide Influences on the Brain and Behavior, Miller LH, Sandman CA, Kastin AJ, eds. New York: Raven Press, pp 127–143Google Scholar
  64. Goldman-Rakic PS (1987): Circuitry of primate prefrontal cortex and regulation of behavior by representational memory. In: Handbook of Physiology, Sec I: The Nervous System, Vol. V: Higher Functions of the Brain, Part1, Plum F, Mountcastle V, eds. Bethesda; MD: Am Physiol Soc, pp 373–417Google Scholar
  65. Goldman-Rakic PS (1990): Cellular and circuit basis of working memory in prefrontal cortex of nonhuman primates. Prog Brain Res 85:325–336Google Scholar
  66. Goldman-Rakic PS, Porrino LJ (1985): The primate mediodorsal (MD) nucleus and its projection to the frontal lobe. J Comp Neurol 242:535–560Google Scholar
  67. Gormezano I (1966): Classical conditioning. In: Experimental Methods and Instrumentation in Psychology, Sidowski JB, ed. New York: McGraw-Hill, pp 385–420Google Scholar
  68. Gormezano I, Kehoe EJ, Marshall BS (1983): Twenty years of classical conditioning research with the rabbit. Prog Psychobiol Physiol Psychol 10:197–275Google Scholar
  69. Graham FK, Clifton RK (1966): Heart-rate change as a component of the orienting response. Psychol Bull 65:305–320Google Scholar
  70. Gray JA (1982): The Neuropsychology of Anxiety: An Inquiry into the Functions of the Septo-hippocampal System. New York: Oxford University PressGoogle Scholar
  71. Groenewegen H (1988): Organization of the afferent connections of the mediodorsal thalamic nucleus in the rat, related to the mediodorsal-prefrontal topography. Neuroscience 24:379–431Google Scholar
  72. Groenewegen HJ, Berendse HW, Wolters JG, Lohman AHM (1990): The anatomical relationship of the prefrontal cortex with the striatopallidal system, the thalamus and the amygdala: Evidence for a parallel organization. Prog Brain Res 85:95–118Google Scholar
  73. Grueninger WE, Kimble DP, Grueninger J, Levine S (1965): GSR and corticosteroid response in monkeys with frontal ablations. Neu-ropsychologia 3:205–216Google Scholar
  74. Hall RE, Livingston RB, Bloor CM (1977): Orbital cortical influences on cardiovascular dynamics and myocardial structure in conscious monkeys. J Neurosurg 46:638–647Google Scholar
  75. Harvey JA, Gormezano I, Coolhauser VA, Schindler CW (1988): Effects of LSD on classical conditioning as a function of CS-UCS interval: Relationship to reflex facilitation. Pharmacol Biochem Behav 30:433–441Google Scholar
  76. Hodes R, Magoun HW (1942a): Autonomic responses to electrical stimulation of forebrain and midbrain with special reference to pupil. J Comp Neurol 76:169–190Google Scholar
  77. Hodes R, Magoun HW (1942b): Pupillary and other responses from stimulation of frontal cortex and basal telencephalon of rat. J Comp Neurol 76:461–472Google Scholar
  78. Hoff EC, Kell JF Jr, Carroll MN Jr (1963): Effects of cortical stimulation and lesions on cardiovascular function. Physiol Rev 43:68–114Google Scholar
  79. Huang Z, Varner KJ, Barman SM, Gebber GL (1988): Diencephalic regions contributing to sympathetic nerve discharge in anesthetized cats. Am J Physiol 254:R249-R256Google Scholar
  80. Hurley KM, Herbert H, Moga MM, Saper CB (1991): Efferent projections of the infralimbic cortex of the rat. J Comp Neurol 308:249–276Google Scholar
  81. Hurley-Guis KM, Neafsey EJ (1986): The medial frontal cortex and gastric motility: Micro-stimulation results and their possible significance for the overall pattern of organization of rat frontal and parietal cortex. Brain Res 365:241–248Google Scholar
  82. Isamat F (1961): Galvanic skin responses from stimulation of limbic cortex. J Neurophysiol 24:176–181Google Scholar
  83. Iwata J, LeDoux JE (1988): Disassociation of associative and nonassociative concomitants of classical fear conditioning in the freely behaving rat. Behav Neurosci 102:66–76Google Scholar
  84. Iwata J, LeDoux JE, Reis DJ (1986): Destruction of intrinsic neurons in the lateral hypothalamus disrupts the classical conditioning of autonomic but not behavioral emotional responses in the rat. Brain Res 386:161–166Google Scholar
  85. Jarrell TW, Romanski LM, Gentile CG, McCabe PM, Schneiderman N (1986): Ibotenic acid lesions in the medial geniculate region prevent the acquisition of differential Pavlovian conditioning of bradycardia to acoustic stimuli in rabbits. Brain Res 382:199–203Google Scholar
  86. Jasper HH (1960): Unspecific thalamocortical relations. In: Handbook of Physiology, Sect 1: Neurophysiology, Vol. II, Field J, Magoun HW, Hall VE, eds. Washington, DC: Am Physiol Soc, pp 1307–1321Google Scholar
  87. Joseph JA, Engle BT (1981): Instrumental control of cardioacceleration induced by central electrical stimulation. Science 214:341–343Google Scholar
  88. Kaada BR (1951): Somato-motor, autonomic and electrocorticographic responses to electrical stimulation of rhinencephalic and other structures in primates, cat and dog. Acta Physiol Scand 23:1–285Google Scholar
  89. Kaada BR (1960): Cingulate, posterior orbital, anterior insular and temporal pole cortex. In: Handbook of Physiology, Sect 1: Neurophysiology, Vol II, Field J, Magoun HW, Hall VE, eds. Washington, DC: Am Physiol Soc, pp 1345–1372Google Scholar
  90. Kao K-T, Powell DA (1988): Lesions of the substantia nigra retard Pavlovian eyeblink but not heart rate conditioning in the rabbit. Behav Neurosci 102:515–525Google Scholar
  91. Kapp BS, Frysinger RC, Gallagher M, Haselton JR (1979): Amygdala central nucleus lesions: Effect on heart rate conditioning in the rabbit. Physiol Behav 23:1109–1117Google Scholar
  92. Kapp BS, Schwaber JS, Driscoll PA (1985a): Frontal cortex projections to the amygdaloid central nucleus in the rabbit. Neuroscience 15:327–346Google Scholar
  93. Kapp BS, Schwaber JS, Driscoll PA (1985b): The Organization of insular cortex projections to the amygdaloid central nucleus and autonomic regulatory nuclei of the dorsal medulla. Brain Res 360:355–360Google Scholar
  94. Katcher AH, Solomon RL, Turner LH, LoLordo V, Overmier JB, Rescorla RA (1969): Heart rate and blood pressure responses to signaled and unsignaled shocks: Effects of cardiac sympathectomy. J Comp Physiol Psychol 68:163–174Google Scholar
  95. Kazis E, Milligan WL, Powell DA (1973): Autonomic-somatic relationships: Blockade of heart rate and corneoretinal potential. J Comp Physiol Psychol 84:98–110Google Scholar
  96. Konorski J (1967): Integrative Activity of the Brain. Chicago: University of Chicago PressGoogle Scholar
  97. Krushel LA, Van Der Kooy D (1988): Visceral cortex: Integration of the mucosal senses with limbic information in the rat agranular insular cortex. J Comp Neurol 270:39–54Google Scholar
  98. Lacey BC, Lacey JI (1974): Studies of heart rate and other bodily processes in sensorimotor behavior. In: Cardiovascular Psychophysiol-ogy: Current Issues in Response, Mechanisms, Biofeedback, and Methodology, Obrist PA, Black AH, Brener J, DiCara LV, eds. Chicago: Aldine, pp 538–564Google Scholar
  99. Lacey BC, Lacey JI (1980): Cognitive modulation of time-dependent primary bradycardia. Psychophysiology 17:209–221Google Scholar
  100. Langworthy OR, Richter CP (1930): The influence of efferent cerebral pathways upon the sympathetic nervous system. Brain 53:178–193Google Scholar
  101. Laroche S, Jay TM, Thierry A (1990): Long-term potentiation in the prefrontal cortex following stimulation of the hippocampal CAl/subicular region. Neurosci Lett 114:184–190Google Scholar
  102. Lavond DG, Logan CG, Sohn JH, Garner WDA, Kansawa SA (1990): Lesions of the cerebellar interpositus nucleus abolish both nictitating membrane and eyelid EMG conditioned responses. Brain Res 514:238–248Google Scholar
  103. LeDoux JE (1987): Emotion. In: Handbook of Physiology, Sect1: The Nervous System, Vol. V: Higher Functions of the Brain, Part 1, Plum F, Mountcastle V, eds. Bethesda, MD: Am Physiol Soc, pp 419–459Google Scholar
  104. LeDoux JE, Cicchetti P, Xagoraris A, Romanski LM (1990): The lateral amygdaloid nucleus: Sensory interface of the amygdala in fear conditioning. J Neurosci 10:1062–1069Google Scholar
  105. LeDoux JE, Sakaguchi A, Reis DJ (1984): Subcortical efferent projections of the medial geniculate nucleus mediate emotional responses conditioned to acoustic stimuli. J Neurosci 4:683–698Google Scholar
  106. Leshner AI, Merkle DA, Mixon JF (1981): Pituitary-adrenocortical effects on learning and memory in social situations. In: Endogenous Peptides and Learning and Memory Processes, Martinez JL Jr, Jensen RA, Messing RB, Rigter H, McGaugh JL, eds. New York: Academic Press, pp 159–179Google Scholar
  107. Livingston RB, Fulton JF, Delgado JMR, Sachs E Jr, Brendler SJ, Davis GD (1948): Stimulation and regional ablation of orbital surface of frontal lobe. Res Publ—Assoc Res Nerv Ment Dis 27:405–420Google Scholar
  108. Lofving B (1961): Cardiovascular adjustments induced from the rostral cingulate gyrus with special reference to sympatho-inhibitory mechanisms. Acta Physiol Scand 53(Suppl 184): 1–82Google Scholar
  109. Markowitsch HJ (1982): Thalamic mediodorsal nucleus and memory: A critical evaluation of studies in animals and man. Neurosci Biobehav Rev 6:351–380Google Scholar
  110. Martinez JL Jr (1986): Memory: Drugs and hormones. In: Learning and Memory: A Biological View, Martinez JL Jr, Kesner RP, eds. Orlando, FL: Academic Press, pp 127–163Google Scholar
  111. McDonald A (1987): Organization of amygdaloid projections to the mediodorsal thalamus and prefrontal cortex: A fluorescence retrograde transport study in the rat. J Comp Neurol 262:46–58Google Scholar
  112. McDonald A (1991): Organization of amygdaloid projections to the prefrontal cortex and associated striatum in the rat. Neuroscience 44:1–14Google Scholar
  113. McGaugh JL (1990): Significance and remembrance: The role of neuromodulatory systems. Psychol Sci 1:15–25Google Scholar
  114. Miller NE (1983): Biofeedback and visceral learning. Annu Rev Psychol 29:373–404Google Scholar
  115. Moore JW, Desmond JE, Berthier NE (1982): The metencephalic basis of the conditioned nictitating membrane response. In: Representation of Involved Neural Functions, Woody CD, ed. New York: Plenum, pp 455–478Google Scholar
  116. Murray K (1967): Operant conditioning. In: Methods in Psychophysiology, Brown CC, ed. Baltimore, MD: Williams & Wilkins, pp 291–310Google Scholar
  117. Nathan MA, Smith OA (1971): Conditional cardiac and suppression responses after lesions in the dorsomedial thalamus of monkeys. J Comp Physiol Psychol 76:66–73Google Scholar
  118. Neafsey EJ (1990): Prefrontal cortical control of the autonomic nervous system: Anatomical and physiological observations. Prog Brain Res 85:147–166Google Scholar
  119. Neafsey EJ, Hurley-Guis KM, Arvanitis D (1986): The topographical organization of neurons in the rat medial frontal, insular and olfactory cortex projecting to the solitary nucleus, olfactory bulb, periaqueductal gray and superior colliculus. Brain Res 377:261–270Google Scholar
  120. Newman PP (1974): Visceral Afferent Functions of the Nervous System. Baltimore, MD: Williams & WilkinsGoogle Scholar
  121. O’Brien CP, Childress AR, McLellan AT, Ehrman R, Ternes JW (1988): Types of conditioning found in drug-dependent humans. In: Learning Factors in Drug Abuse, Ray BA, ed. Washington, DC: US Public Health Service, NIDA Res Monogr 84, pp 44–61Google Scholar
  122. Obrist PA (1981): Cardiovascular Psychophysiology: A Perspective. New York: PlenumGoogle Scholar
  123. Orona E, Gabriel M (1983a): Multiple-unit activity of the prefrontal cortex and mediodorsal thalamic nucleus during acquisition of discriminative avoidance behavior in rabbits. Brain Res 263:295–312Google Scholar
  124. Orona E, Gabriel M (1983b): Multiple-unit activity of the prefrontal cortex and mediodorsal thalamic nucleus during reversal learning of discriminative avoidance behavior in rabbits. Brain Res 263:313–329Google Scholar
  125. Pavlov I (1927): Conditioned Reflexes: An Investigation of the Physiological Activity of the Cerebral Cortex, Anrep GV, transi. New York: Oxford UniversityGoogle Scholar
  126. Powell DA (1979): Peripheral and central muscarinic cholinergic blockade: Effects on Pavlovian conditioning. Bull Psychon Soc 14:161–164Google Scholar
  127. Powell DA, Buchanan SL (1986): Chemical stimulation of the mediodorsal nucleus of the thalamus elicits autonomic adjustments. Pharmacol Biochem Behav 25:423–430Google Scholar
  128. Powell DA, Buchanan SL, Gibbs CM (1990a): Role of the prefrontal-thalamic axis in classical conditioning. Prog Brain Res 85:433–466Google Scholar
  129. Powell DA, Buchanan SL, Hernandez LL (1985): Electrical stimulation of insular cortex elicits cardiovascular adjustments but insular lesions do not abolish conditioned bradycardia. Behav Brain Res 17:125–144Google Scholar
  130. Powell DA, Joseph JA (1974): Autonomicsomatic interaction and hippocampal theta activity. J Comp Physiol Psychol 87:978–986Google Scholar
  131. Powell DA, Kazis E (1976): Blood pressure and heart rate changes accompanying classical eye-blink conditioning in the rabbit (Oryctolagus cuniculus). Psychophysiology 13:441–447Google Scholar
  132. Powell DA, Levine-Bryce D (1988): A comparison of two model systems of associative learning: Heart rate and eyeblink conditioning in the rabbit. Psychophysiology 25:672–682Google Scholar
  133. Powell DA, Levine-Bryce D (1989): Conditioned bradycardia in the rabbit: Effects of knife cuts and ibotenic acid lesions in the lateral hypothalamus. Exp Brain Res 76:103–121Google Scholar
  134. Powell DA, Lipkin M, Milligan WL (1974): Concomitant changes in classically conditioned heart rate and corneoretinal potential discrimination in the rabbit (Oryctolagus cuniculus). Learn Motiv 5:532–547Google Scholar
  135. Powell DA, Mankowski D, Buchanan SL (1978): Concomitant heart rate and corneoretinal potential conditioning in the rabbit (Oryctolagus cuniculus): Effects of caudate lesions. Physiol Behav 20:143–150Google Scholar
  136. Powell DA, Milligan WL (1975): Effects of partial and continuous reinforcement on conditioned heart rate and corneoretinal potential responses in the rabbit (Oryctolagus cuniculus). Psychol Rec 25:419–426Google Scholar
  137. Powell DA, Schneiderman N, Elster AJ, Jacobson A (1971): Differential classical conditioning in rabbits (Oryctolagus cuniculus) to tones and change in illumination. J Comp Physiol Psychol 76:267–274Google Scholar
  138. Powell DA, Watson K (1990): Ibotenic lesions of the prefrontal cortex in the rabbit: Effects on heart rate conditioning. Soc Neurosci Abstr 16:269Google Scholar
  139. Powell DA, Watson K, Buchanan SL (1990b): Neuronal activity in the mediodorsal and intralaminar nuclei of the dorsal thalamus during classical heart rate conditioning. Brain Res 532:211–221Google Scholar
  140. Pribram KH, McGuiness D (1975): Arousal, activation and effort in the control of attention. Psychol Rev 82:116–149Google Scholar
  141. Prokasy WF (1984): Acquisition of skeletal conditioned responses in Pavlovian conditioning. Psychophysiology 21:1–13Google Scholar
  142. Putnam LE, Ross LE, Graham FK (1974): Cardiac orienting during “good” and “poor” differential eyelid conditioning. J Exp Psychol 102:563–573Google Scholar
  143. Reep R (1984): Relationship between prefrontal and limbic cortex: A comparative anatomical review. Brain Behav Evol 25:5–80Google Scholar
  144. Rose J, Woolsey C (1948): The orbitofrontal cortex and its connections with the mediodorsal nucleus in rabbit, sheep and cat. Res Publ— Assoc Res Nerv Ment Dis 27:210–232Google Scholar
  145. Saper CB (1982): Convergence of autonomic and limbic connections in the insular cortex of the rat. J Comp Neurol 210:163–173Google Scholar
  146. Saper CB (1985): Organization of cerebral cortical afferent systems in the rat. II. Hypothala-mocortical projections. J Comp Neurol 237:21–46Google Scholar
  147. Scheibel ME, Scheibel AB (1967): Structural organization of nonspecific thalamic nuclei and their projection toward cortex. Brain Res 6:60–94Google Scholar
  148. Schneiderman N (1972): Response system divergencies in aversive classical conditioning. In: Classical Conditioning II: Current Theory and Research, Black AH, Prokasy WF, eds. New York: Appleton-Century-Crofts, pp 341–376Google Scholar
  149. Schneiderman N, Francis J, Sampson LD, Schwaber JS (1974): CNS integration of learned cardiovascular behavior. In: Limbic and Autonomic Nervous Systems Research, Dicara LV, ed. New York: Plenum, pp 277–309Google Scholar
  150. Schwaber JS, Kapp BS, Higgins GA, Rapp PR (1982): Amygdaloid and basal forebrain direct connections with the nucleus of the solitary tract and the dorsal motor nucleus. J Neurosci 2:1424–1438Google Scholar
  151. Shapiro D, Schwartz GE (1972): Biofeedback and visceral learning: Clinical applications. Semin Psychiatry 4:171–184Google Scholar
  152. Sherrington CS (1900): Experiments on the value of vascular and visceral factor for the genesis of emotion. Proc R Soc London 66:390–403Google Scholar
  153. Shipley MT (1982): Insular cortex projection to the nucleus of the solitary tract and brainstem visceromotor regions in the mouse. Brain Res Bull 8:138–148Google Scholar
  154. Showers MJC, Crosby EC (1958): Somatic and visceral response from the cingulate gyrus. Neurology 8:561–565Google Scholar
  155. Siegel S (1979): The role of conditioning in drug tolerance and addiction. In: Psychopathology in Animals: Research and Clinical Implications, Keehn JD, ed. New York: Academic Press, pp 143–168Google Scholar
  156. Sikes RW, DeFrance JF (1985): Cingulate cortex response to electrical stimulation of the mediodorsal nucleus. Exp Neurol 89:428–441Google Scholar
  157. Skinner JE, Reed JC (1978): Prevention of ventricular fibrillation in the ischemic myocardium of the conscious pig during cryogenic blockade in the thalamic gating system. In: Neural Mechanisms in Cardiac Arrhythmias, Schwartz PJ, Brown AM, Malliani A, Zanchetti A, eds. New York: Raven Press, pp 275–278Google Scholar
  158. Sloan N, Jasper H (1950): Studies of regulatory functions of limbic cortex. Electroencephalogr Clin Neurophysiol 2:317–327Google Scholar
  159. Slotnick BM, Kaneko N (1981): Role of mediodorsal thalamic nucleus in olfactory discrimination learning in rats. Science 214:91–92Google Scholar
  160. Smith OA, DeVito JL (1984): Central neural integration for the control of autonomic responses associated with emotion. Annu Rev Neurosci 7:43–65Google Scholar
  161. Smith OA, Nathan MA, Clarke NP (1968): Central nervous system pathways mediating blood pressure changes. Hypertension 16:9–22Google Scholar
  162. Smith WK (1938): The representation of respiratory movements in the cerebral cortex. J Neurophysiol 1:55–68Google Scholar
  163. Smith WK (1945): The functional significance of the rostral cingular cortex as revealed by its responses to electrical excitation. J Neurophysiol 8:241–255Google Scholar
  164. Sokolov EN (1963): Perception and the Conditioned Reflex. New York: MacmillanGoogle Scholar
  165. Spencer WG (1894): The effect produced upon respiration by faradic excitation of the cerebrum in the monkey, dog, cat and rabbit. Philos Trans R Soc London, Ser B 185:609–657Google Scholar
  166. Staubli U, Schottler F, Nejat-Bina D (1987): Role of dorsomedial thalamic nucleus and piriform cortex in processing olfactory information. Behav Brain Res 25:117–129Google Scholar
  167. Stern JA (1972): Physiological response measures during classical conditioning. In: Handbook of Psychophysiology, Greenfield NS, Steinbach RA, eds. New York: Holt, Rinehart, & Winston, pp 197–227Google Scholar
  168. Sutterer JR, Obrist PA (1972): Heart rate and general activity alterations of dogs during several aversive conditioning procedures. J Comp Physiol Psychol 80:314–326Google Scholar
  169. Terreberry RR, Neafsey EJ (1983): Rat medial frontal cortex: A visceral motor region with a direct projection to the solitary nucleus. Brain Res 278:245–249Google Scholar
  170. Teyler TJ (1971): Effects of restraint on heartrate conditioning in rats as a function of US location. J Comp Physiol Psychol 77:31–37Google Scholar
  171. Thierry A, Godbout R, Mantz J, Glowinski J (1990): Influence of the ascending monoaminergic systems on the activity of the rat prefrontal cortex. Prog Brain Res 85:357–365Google Scholar
  172. Thompson RF (1986): The neurobiology of learning and memory. Science 233:941–947Google Scholar
  173. Thompson RF (1988): The neural basis of basic associative learning of discrete behavioral responses. Trends Neurosci 11:152–155Google Scholar
  174. Thompson RF, Donegan NH, Lavond DG (1988): The psychobiology of learning and memory. In: Stevens Handbook of Experimental Psychology, Atkinson RC, Herrnstein RJ, Lindsey G, Luce RD, eds. New York: Wiley, 2nd ed, Vol 2, pp 245–347Google Scholar
  175. Thorndike EL (1911): Animal Intelligence. New York: MacmillanGoogle Scholar
  176. Uylings HBM, Van Eden CG (1990): Qualitative and quantitative comparison of the prefrontal cortex in rat and in primates, including humans. Prog Brain Res 85:31–62Google Scholar
  177. Van Der Kooy D, Koda LY, McGinty JF, Gerfen CR, Bloom FE (1984): The organization of projections from the cortex, amygdala, and hypothalamus to the nucleus of the solitary tract in rat. J Comp Neurol 224:1–24Google Scholar
  178. Van Der Kooy D, McGinty JF, Koda LY, Gerfen CR, Bloom FE (1982): Visceral cortex: A direct connection from prefrontal cortex to the solitary nucleus in rat. Neurosci Lett 33:123–127Google Scholar
  179. Vanderwolf CH (1971): Limbic-diencephalic mechanisms of voluntary movement. Psychol Rev 78:83–113Google Scholar
  180. Varner KJ, Barman SM, Gebber GL (1988): Cat diencephalic neurons with sympathetic nerve-related activity. Am J Physiol 254:R257–R267Google Scholar
  181. Ward AA Jr (1948): The anterior cingulate gyrus and personality. Res Publ—Assoc Res Nerv Ment Dis 27:438–445Google Scholar
  182. Waring AE, Means LW (1976): The effect of medial thalamic lesions on emotionality, activity, and discrimination learning in the rat. Physiol Behav 17:181–186Google Scholar
  183. Washton AM (1978): Pavlovian conditioning of heart rate in Macaca mulatto: Autonomic and stimulus control of cardiac responding as a function of CS-US interval. Unpublished Ph.D. dissertation, City University of New YorkGoogle Scholar
  184. Weinberger NM, Diamond DM (1987): Physiological plasticity in auditory cortex: Rapid induction by learning. Prog Neurobiol 29:1–55Google Scholar
  185. Weis BJ, Means LW (1980): A comparison of the effects of medial frontal, dorsomedial thalamic, and combination lesions on discrimination and spontaneous alteration in the rat. Physiol Psychol 8:325–329Google Scholar
  186. West CHK, Benjamin RM (1983): Effects of stimulation of the mediodorsal nucleus and its projection cortex on heart rate in the rabbit. J Auton Nerv Syst 9:547–557Google Scholar
  187. Wilcott RC (1968): Cortical control of skin potential, skin resistance and sweating. Psychophysiology 4:500Google Scholar
  188. Yasui Y, Breder CD, Saper CB, Cechetto DF (1991): Autonomic responses and efferent pathways from the insular cortex in the rat. J Comp Neurol 303:355–374Google Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Shirley L. Buchanan
  • Donald A. Powell

There are no affiliations available

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