Effects of Physiological Doses of Female Sex Hormones on the Mechanical and Electrical Behaviour of the Heart
The effect of physical exercise on female sex hormone metabolism has recently been studied (1, 2, 3). It was found that the plasma concentrations of estradiol and progesterone rapidly increased during exercise. It was recently established (4, 5) that the heart can act as a target organ for these hormones via receptor sites within the cytosol. However, a fast reaction of the heart via a receptor mechanism seems to us unlikely since a protein synthesis would have to be involved. Therefore, we investigated the short term effects of these hormones, in the physiological range of concentrations, on the electrical and mechanical activity of isolated rat and rabbit hearts.
KeywordsPressure Development Rabbit Heart Physiological Dose Short Time Delay Isolate Rabbit Heart
Unable to display preview. Download preview PDF.
- 2.J. E. Jurkowski, N. L. Jones, W. C. Walker, E. V. Younglai and J. R. Sutton, Ovarian hormonal response to exercise, J. Appl. Physiol.: Respirát. Environ. Exercise Physiol. 44: 109–114 (1978).Google Scholar
- 3.H. A. Keizer, J. Poortman and G. S. J. Bunnik, Influence of physical exercise on sex-hormone metabolism, J. Appl. Physiol.: Respirát. Environ. Exercise Physiol. 48: 765–769 (1980).Google Scholar
- 7.H. C. Schamhardt and E. L. de Beer, Inseparability between preload and contractility effects on pressure development in the isovolumically contracting rabbit heart, in: “Cardiac Dynamics”, J. Baan, A. C. Arntzenius, E. L. Yellin, ed., Martinus Nijhoff Publishers, the Hague, pg 37–43 (1980).CrossRefGoogle Scholar
- 9.R. Niedergerke and R. K. Orkand, The dual effect of calcium on the action potential of the frog’s heart, J. Physiol. (London) 184: 291–311 (1966).Google Scholar