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Research on the Biochemical Basis of Platelet Function

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The Year in Hematology

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Abstract

Within the past few years there has been a great increase in platelet research by scientists with diverse interests. This is in part because of the relevance of platelet research to major health problems, but also because platelets have proved to be excellent subjects for research into many fundamental cell processes (e.g., contractility, secretion, prostaglandin synthesis, cell adhesion, and cytoplasmic regulatory mechanisms). In this chapter, we briefly summarize the current concepts of platelet function and evaluate the status of research into the biochemical basis of key platelet processes. Our emphasis is on topics that we believe represent the most active areas of platelet research at the molecular level. Reference citations are not complete, but have been selected to validate major points and to refer the reader to more detailed discussions. We regret that space does not permit us to acknowledge many of the key papers that have played such vital parts in developing our understanding of platelets.

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  1. Department of Biochemistry, State University of New York Downstate Medical Center, Brooklyn, New York, 11203, USA

    Thomas C. Detwiler & Israel F. Charo

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  1. Thomas C. Detwiler
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  1. Graduate School of Arts and Science, New York University, New York, New York, USA

    Albert S. Gordon Ph.D., F.R.S.M.  & Joseph LoBue Ph.D.  & 

  2. New York University School of Medicine, New York, New York, USA

    Robert Silber M.D.

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Detwiler, T.C., Charo, I.F. (1977). Research on the Biochemical Basis of Platelet Function. In: Gordon, A.S., Silber, R., LoBue, J. (eds) The Year in Hematology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-6688-9_14

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