Immunological Aspects of Leukemia

  • Ronald B. Herberman


For many years, much attention has been focused on immunological studies in leukemia. This level of attention and effort has been disproportionately high, relative to the clinical frequency of leukemia compared to other types of neoplastic diseases. This may be accounted for by several important factors: (a) A considerable proportion of tumors arising spontaneously or induced in experimental animals, especially rodents, are leukemias or lymphomas. (b) The neoplastic leukemic cells are directly accessible in the peripheral blood or bone marrow, and there has been little or no need to use disaggregation or other procedures to obtain high yields of neoplastic cells. In many instances, it is possible to obtain very large numbers of leukemic cells virtually uncontaminated by normal cells. (c) Compared to carcinomas or sarcomas, it has been relatively easy to obtain the normal cellular counterparts of the various types of leukemic cells. This has provided an unusual opportunity to compare the normal processes of cell differentiation and the normal cell surface markers to the neoplastic processes and leukemia-associated markers.


Depression Sarcoma Myeloma Lysozyme Mitomycin 


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Copyright information

© Springer Science+Business Media New York 1977

Authors and Affiliations

  • Ronald B. Herberman
    • 1
  1. 1.Laboratory of ImmunodiagnosisNational Cancer InstituteBethesdaUSA

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