Regulation of Metabolism

  • Anthony H. Rose

Abstract

It is perhaps self-evident that the metabolism of micro-organisms, and indeed of all living organisms, is under strict in vivo control. Micro-organisms show a remarkable reproducibility in structure and composition, a reproducibility that is maintained even when they are grown in media of widely different chemical composition. Moreover, rapidly growing micro-organisms usually accumulate, either intracellularly or in the environment, only very small quantities of compounds that could be used in synthesis of new cell material, which indicates that there is extremely little wastage during cell metabolism. There are many other examples that could be quoted to show the remarkable degree of control and economy that operates in the metabolism of micro-organisms.

Keywords

Recombination Bacillus Polypeptide Glutamine NADPH 

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References

  1. Adelberg, E. A. and Pittard, J. (1965). Bad. Rev. 29, 161Google Scholar
  2. Atkinson, D. E. (1966). A. Rev. Biochem. 35, 85CrossRefGoogle Scholar
  3. Braun, W. (1966). Bacterial Genetics, 2nd ed. Philadelphia; SaundersGoogle Scholar
  4. Brenner, S., Barnett, L., Katz, E. R. and Crick, F. H. C. (1967). Nature, Lond. 213,449CrossRefGoogle Scholar
  5. Cohen, G. N. (1965). A. Rev. Microbiol. 19, 105CrossRefGoogle Scholar
  6. Crick, F. H. C. (1966). J. molec. Biol. 19, 548PubMedCrossRefGoogle Scholar
  7. Crick, F. H. C. (1967). Broc. R. Soc. B 167, 331CrossRefGoogle Scholar
  8. Datta, P. and Gest, H. (1964). Proc. natn. Acad. Sci. U.S.A. 52, 1004CrossRefGoogle Scholar
  9. Dean, A. C. R. and Hinshelwood, Sir Cyril (1966). Growth, Function and Regulation in Bacterial Cells. Oxford; Clarendon PressGoogle Scholar
  10. De Ley, J. and Schell, J. (1963). J. gen. Microbiol. 33, 243CrossRefGoogle Scholar
  11. Fincham, J. R. S. and Day, P. R. (1963). Fungal Genetics. Oxford; BlackwellsGoogle Scholar
  12. Gilbert, W. and Müller-Hill, B. (1966). Proc. natn. Acad. Sci. U.S.A. 56, 1891CrossRefGoogle Scholar
  13. Grisolia, S. (1964). Physiol. Rev. 44, 657PubMedGoogle Scholar
  14. Hayes, W. (1964). The Genetics of Bacteria and their Viruses. Oxford; BlackwellsGoogle Scholar
  15. Hill, L. R. (1966). J. gen. Microbiol. 44, 419PubMedCrossRefGoogle Scholar
  16. Jacob, F. and Monod, J. (1961). J. molec. Biol. 3, 318PubMedCrossRefGoogle Scholar
  17. Kaplan, S. (1967). Sci. Progr. 55, 223PubMedGoogle Scholar
  18. Kotyk, A. and Kleinzeller, A. (1967). Biochim. biophys. Acta 135, 106PubMedCrossRefGoogle Scholar
  19. Magasanik, B. (1961). Cold Spring Harb. Symp. quant. Biol. 26, 249PubMedCrossRefGoogle Scholar
  20. Monod, J., Changeux, J-P. and Jacob, F. (1963). J. molec. Biol. 6, 306PubMedCrossRefGoogle Scholar
  21. Neidhardt, F. G. (1966). Bact. Rev. 30, 701PubMedGoogle Scholar
  22. Nirenberg, M. and Leder, P. (1964). Science 145, 1399PubMedCrossRefGoogle Scholar
  23. Nishimura, S., Jones, D. S., Ohtsuka, E., Hayatsu, H., Jacob, T. M. and Khorana, H. G. (1965). J. molec. Biol. 13, 283CrossRefGoogle Scholar
  24. Pardee, A. B. (1959). In The Enzymes, vol. 1. ed. by Boyer, P. D., Lardy, H. and Myrbäck, K. New York; Academic PressGoogle Scholar
  25. Roper, J. A. (1966). In The Fungi, vol. 2. ed. by Ainsworth, G. C. and Sussman, A. S. New York; Academic PressGoogle Scholar
  26. Sarabhai, A. S., Stretton, A. O. W., Brenner, S. and Bolle, A. (1964). Nature Lond. 201, 13PubMedCrossRefGoogle Scholar
  27. Spizizen, J., Reilly, B. E. and Evans, A. H. (1966). A. Rev. Microbiol. 20, 371CrossRefGoogle Scholar
  28. Stadtman, E. R. (1963). Bact. Rev. 27, 170PubMedGoogle Scholar
  29. Stadtman, E. R. (1966). Adv. Enzymol. 28, 41PubMedGoogle Scholar
  30. Stretton, A. O. W. (1965). Brit. med. Bull. 21, 229PubMedGoogle Scholar
  31. Szybalski, W. (1967). In Thermobiology ed. by Rose, A. H. London; Academic PressGoogle Scholar
  32. Vogel, H. J. and Vogel, R. H. (1967). A. Rev. Biochem. 36, 519CrossRefGoogle Scholar
  33. Yanofsky, C, Carlton, B. C, Guest, J. R., Helinski, D. R. and Henning, U. (1964). Proc. natn. Acad. Sci. U.S.A. 51, 266CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1968

Authors and Affiliations

  • Anthony H. Rose
    • 1
  1. 1.Biological SciencesBath University of TechnologyBathUK

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